ArticleBiochemistry research international2014
A metabolic study on colon cancer using (1)h nuclear magnetic resonance spectroscopy.
Article in Biochemistry research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Human papillomavirus, vaginal microbiota and metagenomics: the interplay between development and progression of cervical cancer.Frontiers in microbiology · 2024Pooled it
- Novel machine-learning bioinformatics reveal distinct metabolic alterations for enhanced colorectal cancer diagnosis and monitoring.iMetaOmics · 2025Article
- Circulating metabolites as potential biomarkers for the early detection and prognosis surveillance of gastrointestinal cancers.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Serum Colorectal Cancer Biomarkers Unraveled by NMR Metabolomics: Past, Present, and Future.Analytical chemistry · 2022Article
- Global metabolomics profiling of colorectal cancer in Malaysian patients.BioImpacts : BI · 2021Article
- Integrating Two-Dimensional Gas and Liquid Chromatography-Mass Spectrometry for Untargeted Colorectal Cancer Metabolomics: A Proof-of-Principle Study.Metabolites · 2020Article
- Metabolic models predict bacterial passengers in colorectal cancer.Cancer & metabolism · 2020Article
- Global serum metabolomics profiling of colorectal cancer.Molecular and clinical oncology · 2019Review
- Article
- Metabolomics Profiling on Different Stages of Colorectal Cancer: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2018Review
- Oral Microbiota Community Dynamics Associated With Oral Squamous Cell Carcinoma Staging.Frontiers in microbiology · 2018Article
- Staging of colorectal cancer using serum metabolomics withIranian journal of basic medical sciences · 2017Article
- Serum metabolomics analysis for early detection of colorectal cancer.Journal of gastroenterology · 2017Article
- Emerging targets for radioprotection and radiosensitization in radiotherapy.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool.Cancer & metabolism · 2016Article
- Metabolomic Approaches in Cancer Epidemiology.Diseases (Basel, Switzerland) · 2015Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Colorectal carcinoma is the third cause of cancer deaths in the world. For diagnosis, invasive methods like colonoscopy and sigmoidoscopy are used, and noninvasive screening tests are not very accurate. We decided to study the potential of (1)HNMR spectroscopy with metabolomics and chemometrics as a preliminary noninvasive test. We obtained a distinguishing pattern of metabolites and metabolic pathways between colon cancer patient and normal. Methods. Sera were obtained from confirmed colon cancer patients and the same number of healthy controls. Samples were sent for (1)HNMR spectroscopy and analysis was carried out Chenomex and MATLAB software. Metabolites were identified using Human Metabolic Data Base (HDMB) and the main metabolic cycles were identified using Metaboanalyst software. Results. 15 metabolites were identified such as pyridoxine, orotidine, and taurocholic acid. Main metabolic cycles involved were the bile acid biosynthesis, vitamin B6 metabolism, methane metabolism, and glutathione metabolism. Discussion. The main detected metabolic cycles were also reported earlier in different cancers. Our observations corroborated earlier studies that suggest the importance of lowering serum LCA/DCA and increasing vitamin B6 intake to help prevent colon cancer. This work can be looked upon as a preliminary step in using (1)HNMR analysis as a screening test before invasive procedures.
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Registered trials
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