ArticleFrontiers in genetics2014
Disrupted human-pathogen co-evolution: a model for disease.
Article in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of host genetic factors in respiratory tract infectious diseases: systematic review, meta-analyses and field synopsis.Scientific reports · 2015Pooled it
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- Evolution and emergence of Mycobacterium tuberculosis.FEMS microbiology reviews · 2024Review
- Recombination events drives the emergence of ColombianVirulence · 2022Article
- Association between Mycobacterium tuberculosis genotype and diabetes mellitus/hypertension: a molecular study.BMC infectious diseases · 2022Article
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- Interaction betweenPathogens (Basel, Switzerland) · 2021Article
- Lipid droplets and the transcriptome of Mycobacterium tuberculosis from direct sputa: a literature review.Lipids in health and disease · 2021Review
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- Helicobacter pylori infection causes both protective and deleterious effects in human health and disease.Genes and immunity · 2021Review
- Shedding Light on the African Enigma: In Vitro Testing ofMicroorganisms · 2021Article
- Genetics and evolution of tuberculosis pathogenesis: New perspectives and approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Review
- BCG Vaccinations Upregulate Myc, a Central Switch for Improved Glucose Metabolism in Diabetes.iScience · 2020Article
- Genome Sequences of Three Colombian Helicobacter pylori Strains Isolated from Tolimense Patients.Microbiology resource announcements · 2020Article
- Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?PLoS genetics · 2020Article
- Challenges of Immune Response Diversity in the Human Population Concerning New Tuberculosis Diagnostics, Therapies, and Vaccines.Frontiers in cellular and infection microbiology · 2020Article
- Review
- Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch?Current genetic medicine reports · 2018Article
- Phylogeographic diversity and mosaicism of theMobile DNA · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
A major goal in infectious disease research is to identify the human and pathogenic genetic variants that explain differences in microbial pathogenesis. However, neither pathogenic strain nor human genetic variation in isolation has proven adequate to explain the heterogeneity of disease pathology. We suggest that disrupted co-evolution between a pathogen and its human host can explain variation in disease outcomes, and that genome-by-genome interactions should therefore be incorporated into genetic models of disease caused by infectious agents. Genetic epidemiological studies that fail to take both the pathogen and host into account can lead to false and misleading conclusions about disease etiology. We discuss our model in the context of three pathogens, Helicobacter pylori, Mycobacterium tuberculosis and human papillomavirus, and generalize the conditions under which it may be applicable.
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