ReviewFrontiers in integrative neuroscience2014
Frontal eye field, where art thou? Anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations.
Review in Frontiers in integrative neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
162 citing papers in PubMed, 4 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Accurate localization and coactivation profiles of the frontal eye field and inferior frontal junction: an ALE and MACM fMRI meta-analysis.Brain structure & function · 2023Pooled it
- Neural substrates of spatial processing and navigation in blindness: An activation likelihood estimation meta-analysis.Frontiers in neuroscience · 2022Pooled it
- Meta-analytic evidence for a core problem solving network across multiple representational domains.Neuroscience and biobehavioral reviews · 2018Pooled it
- A Systematic Research Review Assessing the Effectiveness of Pursuit Interventions in Spatial Neglect Following Stroke.Translational stroke research · 2015Pooled it
- From convergence insufficiency to functional reorganization: A longitudinal randomized controlled trial of treatment-induced connectivity plasticity.CNS neuroscience & therapeutics · 2024Trial
- Neural correlates of weight-shift training in older adults: a randomized controlled study.Scientific reports · 2023Trial
- Portable eye-tracking as a reliable assessment of oculomotor, cognitive and reaction time function: Normative data for 18-45 year old.PloS one · 2021Trial
- Semantic anomaly detection in school-aged children during natural sentence reading - A study of fixation-related brain potentials.PloS one · 2018Trial
- Mathematics Anxiety Is Associated With Attentional and Memory-Related Neural Activity During Numerical Cognition.Psychophysiology · 2026Article
- Tetrix: A novel Tetris-based paradigm for neuroimaging research and clinical applications.Behavior research methods · 2026Article
- Fixation Task: A Simple Eye Movement Task Reveals an Impairment in Schizophrenia.Schizophrenia bulletin · 2026Article
- Investigating the mechanisms underlying saccade generation in the frontal eye fields using multisite microstimulation.Journal of neurophysiology · 2026Article
- EEG activities and connectivities associated with surtitle presentation during live opera viewing: an exploratory analysis of cognitive absorption.Scientific reports · 2026Article
- Neurophysiological Functional Connectivity Changes during Difficult Listening in Older and Younger Adults.bioRxiv : the preprint server for biology · 2026Article
- The neurocognitive aspects of empathy and theory of mind in pragmatic language processing.Cognitive, affective & behavioral neuroscience · 2026Article
- Functional and Metabolic Abnormalities in Primary Visual Cortex and Frontal Eye Fields and Candidate Biomarkers of Acute Acquired Comitant Esotropia.Investigative ophthalmology & visual science · 2026Article
- Divergent prefrontal activation between genders in depression during verbal fluency task: evidence from a large-scale fNIRS study.Annals of general psychiatry · 2026Article
- Aligned representation of visual and tactile motion directions in hMT+/V5 and fronto-parietal regions.Nature communications · 2026Article
- Visuomotor training induces network reorganisation of frontal eye field and cuneus connectivity: A task-based fMRI study.Neuroimage. Reports · 2026Article
- Rapid modulation of choice behavior by ultrasound on the human frontal eye fields.Nature communications · 2026Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The planning, control and execution of eye movements in 3D space relies on a distributed system of cortical and subcortical brain regions. Within this network, the Eye Fields have been described in animals as cortical regions in which electrical stimulation is able to trigger eye movements and influence their latency or accuracy. This review focuses on the Frontal Eye Field (FEF) a "hub" region located in Humans in the vicinity of the pre-central sulcus and the dorsal-most portion of the superior frontal sulcus. The straightforward localization of the FEF through electrical stimulation in animals is difficult to translate to the healthy human brain, particularly with non-invasive neuroimaging techniques. Hence, in the first part of this review, we describe attempts made to characterize the anatomical localization of this area in the human brain. The outcome of functional Magnetic Resonance Imaging (fMRI), Magneto-encephalography (MEG) and particularly, non-invasive mapping methods such a Transcranial Magnetic Stimulation (TMS) are described and the variability of FEF localization across individuals and mapping techniques are discussed. In the second part of this review, we will address the role of the FEF. We explore its involvement both in the physiology of fixation, saccade, pursuit, and vergence movements and in associated cognitive processes such as attentional orienting, visual awareness and perceptual modulation. Finally in the third part, we review recent evidence suggesting the high level of malleability and plasticity of these regions and associated networks to non-invasive stimulation. The exploratory, diagnostic, and therapeutic interest of such interventions for the modulation and improvement of perception in 3D space are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.