ArticleJournal of the mechanics and physics of solids2014
The role of mechanics during brain development.
Article in Journal of the mechanics and physics of solids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 244 citations in OpenAlex.
- A Mechanical Theory for the Formation of Short Association Fibers in the Brain.bioRxiv : the preprint server for biology · 2026Article
- Mechanochemical modeling of exercise-induced skeletal muscle hypertrophy.PLoS computational biology · 2026Article
- Necking of epithelial tissues with cellular topological transition.PLoS computational biology · 2026Article
- Spatial scale of indentation explains shift in ratio between spinal cord gray and white matter stiffness.Scientific reports · 2026Article
- Mechanics of the Spatiotemporal Evolution of Sulcal Pits in the Folding Brain.Human brain mapping · 2025Article
- Differential patterns of cortical expansion in fetal and preterm brain development.bioRxiv : the preprint server for biology · 2025Article
- Exploring hyperelastic material model discovery for human brain cortex: Multivariate analysis vs. artificial neural network approaches.Journal of the mechanical behavior of biomedical materials · 2025Article
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- Numerical investigation of new rete ridge formation in a multi-layer model of skin subjected to tissue expansion.Journal of biomechanics · 2024Article
- Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.ACS photonics · 2024Review
- Shaping the brain: The emergence of cortical structure and folding.Developmental cell · 2023Review
- Multi-scale measurement of stiffness in the developing ferret brain.Scientific reports · 2023Article
- An integrated finite element method and machine learning algorithm for brain morphology prediction.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Morphoelastic modelling of pattern development in the petal epidermal cell cuticle.Journal of the Royal Society, Interface · 2023Article
- Proliferating active matter.Nature reviews. Physics · 2023Review
- Exploring the role of the outer subventricular zone during cortical folding through a physics-based model.eLife · 2023Article
- Exploring the multiphysics of the brain during development, aging, and in neurological diseases.Brain multiphysics · 2023Article
- Functional bioengineered models of the central nervous system.Nature reviews bioengineering · 2023Review
- Modelling brain tissue elasticity with the Ogden model and an alternative family of constitutive modelsPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Convolutions are a classical hallmark of most mammalian brains. Brain surface morphology is often associated with intelligence and closely correlated to neurological dysfunction. Yet, we know surprisingly little about the underlying mechanisms of cortical folding. Here we identify the role of the key anatomic players during the folding process: cortical thickness, stiffness, and growth. To establish estimates for the critical time, pressure, and the wavelength at the onset of folding, we derive an analytical model using the Föppl-von-Kármán theory. Analytical modeling provides a quick first insight into the critical conditions at the onset of folding, yet it fails to predict the evolution of complex instability patterns in the post-critical regime. To predict realistic surface morphologies, we establish a computational model using the continuum theory of finite growth. Computational modeling not only confirms our analytical estimates, but is also capable of predicting the formation of complex surface morphologies with asymmetric patterns and secondary folds. Taken together, our analytical and computational models explain why larger mammalian brains tend to be more convoluted than smaller brains. Both models provide mechanistic interpretations of the classical malformations of lissencephaly and polymicrogyria. Understanding the process of cortical folding in the mammalian brain has direct implications on the diagnostics of neurological disorders including severe retardation, epilepsy, schizophrenia, and autism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.