ArticleAmerican journal of Alzheimer's disease and other dementias2015
Effects of alcohol consumption on cognition and regional brain volumes among older adults.
Article in American journal of Alzheimer's disease and other dementias, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term effects of alcohol consumption on cognitive function: a systematic review and dose-response analysis of evidence published between 2007 and 2018.Systematic reviews · 2020Pooled it
- Impairment of the frontal lobe in late-onset fetal growth restriction: is it detectable in fetuses with a normal cerebroplacental ratio?BMC pregnancy and childbirth · 2026Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- Article
- Exploring sexual dimorphism in basal forebrain volume changes during aging and neurodegenerative diseases.iScience · 2024Article
- Determinants of semantic and episodic memory decline among older adults in Ghana: Evidence from the WHO study on global AGEing and adult health Ghana wave 2.Dialogues in health · 2023Article
- Longitudinal dimensions of alcohol consumption and dietary intake in the Framingham Heart Study Offspring Cohort (1971-2008).The British journal of nutrition · 2021Article
- Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study.Journal of neurology · 2020Article
- Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Alcohol Consumption, Brain Amyloid-β Deposition, and Brain Structural Integrity Among Older Adults Free of Dementia.Journal of Alzheimer's disease : JAD · 2020Article
- The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer's Disease.Nutrients · 2019Review
- Alcohol consumption behaviors and neurocognitive dysfunction and emotional distress in adult survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.Addiction (Abingdon, England) · 2019Article
- Clarifying the neurobehavioral sequelae of moderate drinking lifestyles and acute alcohol effects with aging.International review of neurobiology · 2019Review
- Heavy Alcohol Use and Age Effects on HIV-Associated Neurocognitive Function.Alcoholism, clinical and experimental research · 2019Article
- Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians.Psychopharmacology · 2018Article
- Factors Influencing Clinical Correlates of Chronic Traumatic Encephalopathy (CTE): a Review.Neuropsychology review · 2016Review
- Current Heavy Alcohol Consumption is Associated with Greater Cognitive Impairment in Older Adults.Alcoholism, clinical and experimental research · 2016Article
- Alcohol Consumption, Left Atrial Diameter, and Atrial Fibrillation.Journal of the American Heart Association · 2016Observational
- Alcohol Versus Cannabinoids: A Review of Their Opposite Neuro-Immunomodulatory Effects and Future Therapeutic Potentials.Journal of alcoholism and drug dependence · 2015Article
- The Association between Late-Life Alcohol Consumption and Incident Dementia among Mexican Americans Aged 75 and Older.Gerontology & geriatric medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This study utilized data from the Framingham Heart Study Offspring Cohort to examine the relationship between midlife and late-life alcohol consumption, cognitive functioning, and regional brain volumes among older adults without dementia or a history of abusing alcohol. The results from multiple linear regression models indicate that late life, but not midlife, alcohol consumption status is associated with episodic memory and hippocampal volume. Compared to late life abstainers, moderate consumers had larger hippocampal volume, and light consumers had higher episodic memory. The differences in episodic memory according to late life alcohol consumption status were no longer significant when hippocampal volume was included in the regression model. The findings from this study provide new evidence that hippocampal volume may contribute to the observed differences in episodic memory among older adults and late life alcohol consumption status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.