ArticleJournal of neurovirology2014
A history of alcohol dependence augments HIV-associated neurocognitive deficits in persons aged 60 and older.
Article in Journal of neurovirology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Review
- Anterior and posterior thalamic volumes differentially correlate with memory, attention, and motor processes in HIV infection and alcohol use disorder comorbidity.Brain research bulletin · 2024Article
- Moderate-to-severe cognitive impairment is associated with both recent and chronic alcohol misuse in people with HIV: The New Orleans alcohol use in HIV (NOAH) study.Alcohol, clinical & experimental research · 2024Article
- Effects of unhealthy alcohol use on brain morphometry and neurocognitive function among people with HIV.Journal of neurovirology · 2022Article
- The Role of Alcohol-Related Behavioral Research in the Design of HIV Secondary Prevention Interventions in the Era of Antiretroviral Therapy: Targeted Research Priorities Moving Forward.AIDS and behavior · 2021Article
- Neuroimaging and Cognitive Evidence for Combined HIV-Alcohol Effects on the Central Nervous System: A Review.Alcoholism, clinical and experimental research · 2021Article
- Alcohol consumption and neurocognitive deficits in people with well-treated HIV in Switzerland.PloS one · 2021Article
- Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity.AIDS (London, England) · 2020Article
- Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review.Neuropsychology · 2019Review
- Novel Machine Learning Identifies Brain Patterns Distinguishing Diagnostic Membership of Human Immunodeficiency Virus, Alcoholism, and Their Comorbidity of Individuals.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Data-Driven Exploration of Brain Structure Using Statistical Machine Learning: Validity of Derived Diagnostic Patterns in Alcohol Use Disorder and Human Immunodeficiency Virus Infection.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Age of Last Alcohol Use Disorder Relates to Processing Speed Among Older Adults Living with HIV.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- Chronic Binge Alcohol-Associated Differential Brain Region Modulation of Growth Factor Signaling Pathways and Neuroinflammation in Simian Immunodeficiency Virus-Infected Male Macaques.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- Heavy Alcohol Use and Age Effects on HIV-Associated Neurocognitive Function.Alcoholism, clinical and experimental research · 2019Article
- Neurologic Complications of Human Immunodeficiency Virus Infection.Continuum (Minneapolis, Minn.) · 2018Review
- HIV/AIDS and an overweight body mass are associated with excessive intra-individual variability in response preparation.Journal of neurovirology · 2018Article
- Multi-Label Transduction for Identifying Disease Comorbidity Patterns.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2018Article
- Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings.Alcohol and alcoholism (Oxford, Oxfordshire) · 2018Review
- Accelerated and accentuated neurocognitive aging in HIV infection.Journal of neurovirology · 2017Article
- Impairments in Component Processes of Executive Function and Episodic Memory in Alcoholism, HIV Infection, and HIV Infection with Alcoholism Comorbidity.Alcoholism, clinical and experimental research · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Excessive alcohol use is common among people living with HIV. Given the growing prevalence of older HIV+ adults and observations indicating higher risk for neurocognitive impairment in older adults with either HIV infection or alcoholism, an increased understanding of their combined impact in the context of this increasingly aged population is crucial. We conducted comprehensive neurocognitive assessment in 112 older HIV+ individuals aged 50 to 69 years. Regression analyses were conducted to examine the interaction between age and the presence of lifetime alcohol dependence on neurocognitive measures, controlling for years of education, hepatitis C serostatus, and lifetime non-alcohol substance use disorder. Significant interactions of age and alcohol dependence history were found for global neurocognitive function, which was driven by the domains of executive function, processing speed, and semantic memory. Follow-up analyses indicated adverse effects of alcohol use history on neurocognitive measures that were evident only in HIV+ individuals 60 years and older. While mounting evidence in younger cohorts indicates adverse synergistic HIV/alcohol effects on neurocognitive function, our novel preliminary findings in this elderly HIV+ cohort demonstrated the importance of even a relatively distant alcohol use history on the expression of HIV-associated neurocognitive disorders that may not become apparent until much later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.