ArticleOccupational and environmental medicine2014
A case-control study of occupational exposure to metalworking fluids and bladder cancer risk among men.
Article in Occupational and environmental medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating temporal trends from occupational lead exposure data reported in the published literature using meta-regression.The Annals of occupational hygiene · 2014Pooled it
- Whole-body inhalation study of nanoparticle-enhanced vegetable oil metalworking fluids in mice for assessing occupational health risks.Scientific reports · 2025Article
- Effect of smoking on the recurrence and progression of non-muscle-invasive bladder cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Review
- 5-alpha reductase inhibitors (5-ARi) with or without alpha-blockers (α-B) for Benign Prostatic Hyperplasia do NOT lower the risk of incident Bladder Cancer: United States insurance claims data.World journal of urology · 2023Article
- Differential Expression of LncRNA in Bladder Cancer Development.Diagnostics (Basel, Switzerland) · 2023Article
- The impacts ofJournal of Cancer · 2023Article
- Adapting Decision Rules to Estimate Occupational Metalworking Fluid Exposure in a Case-Control Study of Bladder Cancer in Spain.Annals of work exposures and health · 2022Article
- Scoping Review of 5 Common Occupational Cancers and Their Related Exposures.Medical journal of the Islamic Republic of Iran · 2022Article
- Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990-2019.Military Medical Research · 2021Article
- Combination of histological and molecular data for improving outcome prediction in non-muscle invasive bladder cancer-narrative review.Translational cancer research · 2020Review
- Role of microRNA/Epithelial-to-Mesenchymal Transition Axis in the Metastasis of Bladder Cancer.Biomolecules · 2020Review
- Early Effect Markers and Exposure Determinants of Metalworking Fluids Among Metal Industry Workers: Protocol for a Field Study.JMIR research protocols · 2019Article
- New insights on occupational exposure and bladder cancer risk: a pooled analysis of two Italian case-control studies.International archives of occupational and environmental health · 2019Article
- Article
- Evaluating predictors of lead exposure for activities disturbing materials painted with or containing lead using historic published data from U.S. workplaces.American journal of industrial medicine · 2017Article
- Smoking status, usual adult occupation, and risk of recurrent urothelial bladder carcinoma: data from The Cancer Genome Atlas (TCGA) Project.Cancer causes & control : CCC · 2016Article
- Risk of renal cell carcinoma following exposure to metalworking fluids among autoworkers.Occupational and environmental medicine · 2016Article
- Occupational exposure to pesticides and bladder cancer risk.International journal of epidemiology · 2016Article
- Response.Journal of the National Cancer Institute · 2016Article
- Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms.Journal of the National Cancer Institute · 2015Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
objectivesMetalworking has been associated with an excess risk of bladder cancer in over 20 studies. Metalworking fluids (MWFs) are suspected as the responsible exposure, but epidemiological data are limited. We investigated this association among men in the New England Bladder Cancer Study using state-of-the-art, quantitative exposure assessment methods.
methodsCases (n=895) and population controls (n=1031) provided occupational histories during personal interviews. For selected jobs, exposure-oriented modules were administered to collect information on use of three MWF types: (1) straight (mineral oil, additives), (2) soluble (mineral oil, water, additives) and (3) synthetic (water, organics, additives) or semisynthetic (hybrid of soluble and synthetic). We computed ORs and 95% CIs relating bladder cancer risk to a variety of exposure metrics, adjusting for smoking and other factors. Non-metalworkers who had held jobs with possible exposure to mineral oil were analysed separately.
resultsBladder cancer risk was elevated among men who reported using straight MWFs (OR=1.7, 95% CI 1.1 to 2.8); risk increased monotonically with increasing cumulative exposure (p=0.041). Use of soluble MWFs was associated with a 50% increased risk (95% CI 0.96 to 2.5). ORs were non-significantly elevated for synthetic/semisynthetic MWFs based on a small number of exposed men. Non-metalworkers holding jobs with possible exposure to mineral oil had a 40% increased risk (95% CI 1.1 to 1.8).
conclusionsExposure to straight MWFs was associated with a significantly increased bladder cancer risk, as was employment in non-metalworking jobs with possible exposure to mineral oil. These findings strengthen prior evidence for mineral oil as a bladder carcinogen.
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