ArticleScientific reports2014
Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 120 citations in OpenAlex.
- Biological and Habitual Factors That Influence Sleep and Circadian Rhythm: A Narrative Review.Cureus · 2026Review
- Afternoon exercise was associated with greater fat loss than morning exercise in overweight/obese adults: an exploratory study of PER3 rs228697 genotype matching.Frontiers in physiology · 2026Article
- Adolescent circadian sleep health: a review of multimodal assessment strategies and clinical implications.Frontiers in sleep · 2026Review
- Study on the Mechanism of Mongolian Medical Warm Acupuncture in Regulating Biological Clock Genes and Improving Sleep in Insomniac Rats.Current medicinal chemistry · 2026Article
- Multilevel factors associated with sleep duration and bedtime regularity in U.S. children with and without neurodevelopmental disorders: a nationally representative study.World journal of pediatrics : WJP · 2025Article
- Multi-SNP Haplotypes in CircadianGenes · 2025Article
- Stable interindividual differences in modafinil's effect on vigilance during sleep deprivation.Frontiers in pharmacology · 2025Article
- Association between PER and CRY gene polymorphisms and the response to caffeine citrate treatment in infants with apnea of prematurity.Frontiers in pediatrics · 2024Article
- Machine learning analyses reveal circadian clock features predictive of anxiety among UK biobank participants.Scientific reports · 2023Article
- Article
- Healthy sleep score changes and incident cardiovascular disease in European prospective community-based cohorts.European heart journal · 2023Article
- Circadian Gene Variants in Diseases.Genes · 2023Review
- Article
- Scalable mixed model methods for set-based association studies on large-scale categorical data analysis and its application to exome-sequencing data in UK Biobank.American journal of human genetics · 2023Article
- Relationship betweenInternational journal of environmental research and public health · 2023Article
- Effects of Work Stress andInternational journal of environmental research and public health · 2022Article
- Machine learning and expression analyses reveal circadian clock features predictive of anxiety.Scientific reports · 2022Article
- Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice.Current issues in molecular biology · 2022Article
- Machine Learning Analyses Reveal Circadian Features Predictive of Risk for Sleep Disturbance.Nature and science of sleep · 2022Article
- Article
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorphisms in circadian clock genes in 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls. The clock gene polymorphisms were tested for associations with diurnal preference and circadian rhythm sleep disorder (CRSD) phenotypes. The PER3 polymorphism (rs228697) was significantly associated with diurnal preference and the FRT phenotype. The minor allele of rs228697 was more prevalent in evening types than in morning types (sex-adjusted odds ratio (OR), 2.483, Bonferroni-corrected P = 0.012) and in FRT individuals compared with the controls (age- and sex-adjusted OR, 2.021, permutated P = 0.017). Our findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes.
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