Evidence map›Paper›PMID 25200663›Full record

ReviewNature reviews. Genetics2014

Eusocial insects as emerging models for behavioural epigenetics.

Hua Yan, Daniel F Simola, Roberto Bonasio, Jürgen Liebig, Shelley L Berger, Danny Reinberg

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 211 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. The Pheromone Landscape ofMolecules (Basel, Switzerland) · 2025
    Review
  5. Molecular mechanisms underlying the evolution of a color polyphenism by genetic accommodation in the tobacco hornworm,Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Roles of DNA Methylation in Color Alternation of Eastern Honey Bees (International journal of molecular sciences · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Molecular patterns and processes in evolving sociality: lessons from insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hua Yan1] Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016, USA. [2].
Daniel F Simola1] Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [2] Epigenetics Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [3].
Roberto Bonasio1] Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [2] Epigenetics Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Jürgen LiebigSchool of Life Sciences, Arizona State University, Tempe, Arizona 85287-4501, USA.
Shelley L Berger1] Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [2] Epigenetics Program, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [3] Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [4] Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Danny Reinberg1] Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York 10016, USA. [2] Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA.
University of Pennsylvania · USNew York University · USArizona State University · US

Funding

Howard Hughes Medical Institute 2009005
6 · The paper itself

Abstract

Understanding the molecular basis of how behavioural states are established, maintained and altered by environmental cues is an area of considerable and growing interest. Epigenetic processes, including methylation of DNA and post-translational modification of histones, dynamically modulate activity-dependent gene expression in neurons and can therefore have important regulatory roles in shaping behavioural responses to environmental cues. Several eusocial insect species - with their unique displays of behavioural plasticity due to age, morphology and social context - have emerged as models to investigate the genetic and epigenetic underpinnings of animal social behaviour. This Review summarizes recent studies in the epigenetics of social behaviour and offers perspectives on emerging trends and prospects for establishing genetic tools in eusocial insects.

Indexed as

Behavior, AnimalModels, AnimalSocial BehaviorAnimalsEpigenesis, GeneticGene-Environment InteractionGenomic InstabilityInsectaTranscription, Genetic

Identifiers

PMID25200663
OpenAlexW2065365453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.