ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2015
Asthma and allergy development: contrasting influences of yeasts and other fungal exposures.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Childhood asthma and mould in homes-A meta-analysis.Wiener klinische Wochenschrift · 2025Pooled it
- Molecular and culture-based identification of Aspergillus species in water-impacted homes following Hurricane María in Puerto Rico.Scientific reports · 2025Article
- Fungal Microbiome Diversity in Urban Forest Decreases Asthma and Allergic Inflammation.Allergy, asthma & immunology research · 2025Article
- Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies.The Journal of allergy and clinical immunology · 2025Review
- Yeasts Prefer Daycares and Molds Prefer Private Homes.Microbial ecology · 2025Article
- Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study.Annals of the American Thoracic Society · 2023Article
- PersistingFrontiers in cellular and infection microbiology · 2023Article
- Into the wild: How exposure to wild or domesticated fungi shapes immune responses in mice.PLoS pathogens · 2022Article
- Mycobiota and the Contribution of Yeasts in Floor Dust of 50 Elementary Schools Characterized with Sequencing Internal Transcribed Spacer Region of Ribosomal DNA.Environmental science & technology · 2022Article
- Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM).Scientific reports · 2022Article
- Vishniacozyma victoriae (syn. Cryptococcus victoriae) in the homes of asthmatic and non-asthmatic children in New York City.Journal of exposure science & environmental epidemiology · 2022Article
- Bacterial and Fungal Adaptations in Cecum and Distal Colon of Piglets Fed With Dairy-Based Milk Formula in Comparison With Human Milk.Frontiers in microbiology · 2022Article
- Household mold, pesticide use, and childhood asthma: A nationwide study in the U.S.International journal of hygiene and environmental health · 2021Article
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- The Fungal Microbiome and Asthma.Frontiers in cellular and infection microbiology · 2020Review
- Environment and Host-Genetic Determinants in Early Development of Allergic Asthma: Contribution of Fungi.Frontiers in immunology · 2019Review
- Bedroom Allergen Exposure Beyond House Dust Mites.Current allergy and asthma reports · 2018Review
- Indoor mould exposure, asthma and rhinitis: findings from systematic reviews and recent longitudinal studies.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- NIAID, NIEHS, NHLBI, and MCAN Workshop Report: The indoor environment and childhood asthma-implications for home environmental intervention in asthma prevention and management.The Journal of allergy and clinical immunology · 2017Article
- Mold and dampness exposure and allergic outcomes from birth to adolescence: data from the BAMSE cohort.Allergy · 2017Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundInfancy is a developmental stage with heightened susceptibility to environmental influences on the risk of chronic childhood disease. Few birth cohort studies have detailed measures of fungal diversity data in infants' bedrooms, limiting the potential to measure long-term associations of these complex exposures with development of asthma or allergy.
objectiveWe evaluated the relation of home fungal levels in infancy to repeated measures of wheeze and development of asthma and rhinitis by age 13, and sensitization by age 12 years.
methodsIn the Epidemiology of Home Allergens and Asthma prospective birth cohort study, we recruited 408 children with family history of allergic disease or asthma. When children were aged 2-3 months, we measured culturable fungi in bedroom air and dust, and in outdoor air. Main outcomes included ascertainment of symptoms/disease onset by questionnaire from birth through age 13. We estimated hazard ratios and, for wheeze and sensitization, odds ratios for an interquartile increase in log-transformed fungal concentrations, adjusting for other outcome predictors and potential confounders.
resultsElevated levels of yeasts in bedroom floor dust were associated with reduced: i) wheeze at any age; ii) fungal sensitization; and iii) asthma development by age 13 (hazard ratio (HR) = 0.86; 95% confidence interval (CI), [0.75 to 0.98]). Outdoor airborne Cladosporium and dustborne Aspergillus predicted increased rhinitis. Risk of fungal sensitization by age 12, in response to environmental Alternaria and Aspergillus, was elevated in children with a maternal history of fungal sensitization. CONCLUSIONS AND CLINICAL RELEVANCE: Despite the irritant and allergenic properties of fungi, early-life elevated dust yeast exposures or their components may be protective against allergy and asthma in children at risk for these outcomes. Ascertainment of fungal components associated with immunoprotective effects may have therapeutic relevance for asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.