ArticleBehavioural brain research2014
Two weeks of predatory stress induces anxiety-like behavior with co-morbid depressive-like behavior in adult male mice.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Chronic corticosterone administration alters synaptic mitochondrial function within the hippocampus of C57Bl/6NTac mice.Physiology & behavior · 2024Article
- Shaping behaviors through social experience and their proposed sensitivity to stress.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- SUMOylation and Major Depressive Disorder.International journal of molecular sciences · 2022Review
- Immune receptor toll-like receptor 4 contributes to stress-induced affective responses in a sex-specific manner.Brain, behavior, & immunity - health · 2021Article
- Inducible and Conditional Stimulation of Adult Hippocampal Neurogenesis Rescues Cadmium-Induced Impairments of Adult Hippocampal Neurogenesis and Hippocampus-Dependent Memory in Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Traumatic stress history interacts with sex and chronic peripheral inflammation to alter mitochondrial function of synaptosomes.Brain, behavior, and immunity · 2020Article
- Chronic repeated predatory stress induces resistance to quinine adulteration of ethanol in male mice.Behavioural brain research · 2020Article
- Animal models of major depression: drawbacks and challenges.Journal of neural transmission (Vienna, Austria : 1996) · 2019Review
- Adult Neurogenesis, Glia, and the Extracellular Matrix.Cell stem cell · 2019Review
- Predator stress-induced depression is associated with inhibition of hippocampal neurogenesis in adult male mice.Neural regeneration research · 2019Article
- The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour.Scientific reports · 2017Article
- GNB3 overexpression causes obesity and metabolic syndrome.PloS one · 2017Article
- Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice.Brain, behavior, and immunity · 2017Article
- Posttraumatic stress disorder: A metabolic disorder in disguise?Experimental neurology · 2016Review
- Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the post-stroke depressive state in rats.Behavioral and brain functions : BBF · 2015Article
- Repeated social defeat stress enhances the anxiogenic effect of bright light on operant reward-seeking behavior in rats.Behavioural brain research · 2015Article
- Enhanced aggressive behaviour in a mouse model of depression.Neurotoxicity research · 2015Article
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Authors and funding
9 authors.
Funding
Abstract
Psychological stress can have devastating and lasting effects on a variety of behaviors, especially those associated with mental illnesses such as anxiety and depression. Animal models of chronic stress are frequently used to elucidate the mechanisms underlying the relationship between stress and mental health disorders and to develop improved treatment options. The current study expands upon a novel chronic stress paradigm for mice: predatory stress. The predatory stress model incorporates the natural predator-prey relationship that exists among rats and mice and allows for greater interaction between the animals, in turn increasing the extent of the stressful experience. In this study, we evaluated the behavioral effects of exposure to 15 days of predatory stress on an array of behavioral indices. Up to 2 weeks after the end of stress, adult male mice showed an increase of anxiety-like behaviors as measured by the open field and social interaction tests. Animals also expressed an increase in depressive-like behavior in the sucrose preference test. Notably, performance on the novel object recognition task, a memory test, improved after predatory stress. Taken as a whole, our results indicate that 15 exposures to this innovative predatory stress paradigm are sufficient to elicit robust anxiety-like behaviors with evidence of co-morbid depressive-like behavior, as well as changes in cognitive behavior in male mice.
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