Evidence map›Paper›PMID 25200374›Full record

ArticleUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2015

Changes in shear wave speed pre- and post-induction of labor: a feasibility study.

L C Carlson, S T Romero, M L Palmeri, A Muñoz Del Rio, S M Esplin, V M Rotemberg, T J Hall, H Feltovich

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In one paragraph

Article in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 60 citations in OpenAlex.

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  6. In vivo Raman spectroscopy monitors cervical change during labor.American journal of obstetrics and gynecology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

L C CarlsonMedical Physics Department, University of Wisconsin, Madison, WI, USA.
S T RomeroDivision of Maternal Fetal Medicine, Intermountain Healthcare, Murray, UT, USA.
M L PalmeriBiomedical Engineering Department, Duke University, Durham, NC, USA.
A Muñoz Del RioMedical Physics Department, University of Wisconsin, Madison, WI, USA.
S M EsplinDivision of Maternal Fetal Medicine, Intermountain Healthcare, Murray, UT, USA.
V M RotembergBiomedical Engineering Department, Duke University, Durham, NC, USA.
T J HallMedical Physics Department, University of Wisconsin, Madison, WI, USA.
H FeltovichMedical Physics Department, University of Wisconsin, Madison, WI, USA.
Intermountain Healthcare · USDuke University · USUniversity of Wisconsin–Madison · USUniversity of Wisconsin System · US

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Monitoring Changes in Cervical Microstructure During PregnancyR01HD072077 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI FELTOVICH, HELEN, HALL, TIMOTHY J · 2013 to 2022
$6.1M
Quantifying Cervical Softness with Elasticity ImagingR21HD063031 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI FELTOVICH, HELEN, HALL, TIMOTHY J · 2010 to 2011
$415k
Detecting changes in cervical microstructure with quantitative ultrasoundR21HD061896 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI HALL, TIMOTHY J · 2009 to 2010
$395k
NCI NIH HHS T32 CA009206NICHD NIH HHS R01 HD072077NICHD NIH HHS R21 HD061896NICHD NIH HHS R21 HD063031NICHD NIH HHS R21HD063031
6 · The paper itself

Abstract

objectiveTo explore the feasibility of using shear wave speed (SWS) estimates to detect differences in cervical softening pre- and post-ripening in women undergoing induction of labor.

methodsSubjects at 37-41 weeks' gestation undergoing cervical ripening before induction of labor were recruited (n = 20). Examinations, performed prior to administration of misoprostol and 4 h later included Bishop score, transvaginal ultrasound measurement of cervical length, and 10 replicate SWS measurements using an ultrasound system equipped with a prototype transducer (128 element, 3 mm diameter, 14 mm aperture) attached to the clinician's hand. Subjects were divided into two groups, 'not-in-labor' and 'marked-progression', based on cervical evaluation at the second examination. Measurements were compared via individual paired hypotheses tests and using a linear mixed model, with the latter also used to compare groups. Spearman's rank correlation coefficient was used to compare SWS with Bishop score. The linear mixed model can take into account clustered data and accommodate multiple predictors simultaneously.

resultsThe Wilcoxon signed-rank paired test established a significant difference in pre- and post-ripening SWS, with mean SWS estimates of 2.53 ± 0.75 and 1.54 ± 0.31 m/s, respectively (P < 0.001) in the not-in-labor group (decrease in stiffness) and 1.58 ± 0.33 and 2.35 ± 0.65 m/s for the marked-progression group (increase in stiffness). The linear mixed model corroborated significant differences in pre- and post-ripening measurements in individual subjects (P < 0.001) as well as between groups (P < 0.0001). SWS estimates were significantly correlated with digitally-assessed cervical softness and marginally correlated with Bishop score as assessed by Spearman's rank correlation coefficient.

conclusionsIn-vivo SWS estimates detected stiffness differences before and after misoprostol-induced softening in term pregnancies. This ultrasonic shear elasticity imaging technique shows promise for assessing cervical softness.

Indexed as

Cervical RipeningCervix UteriFeasibility StudiesFemaleHumansLabor, InducedMisoprostolOxytocicsPregnancyUltrasonographyMisoprostolOxytocicscervixinduction of laborshear wave speed

Identifiers

PMID25200374
PMCPMC4363009
OpenAlexW2155343033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.