ReviewDiabetes, obesity & metabolism2014
Brain glucose sensing, glucokinase and neural control of metabolism and islet function.
Review in Diabetes, obesity & metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Analysis of rare coding variants in 470,000 exome-sequenced subjects characterises contributions to risk of type 2 diabetes.PloS one · 2024Article
- Nutrient sensors and their crosstalk.Experimental & molecular medicine · 2023Review
- Study on the Hyperglycemic Effect of GLP-1 inAquaculture nutrition · 2023Article
- Simultaneous exposure to electromagnetic field from mobile phone and unimpeded fructose drinking during pre-, peri-, and post-pubertal stages perturbs the hypothalamic and hepatic regulation of energy homeostasis by early adulthood: experimental evidence.Environmental science and pollution research international · 2022Article
- Interplay between bioenergetics and oxidative stress at normal brain aging. Aging as a result of increasing disbalance in the system oxidative stress-energy provision.Pflugers Archiv : European journal of physiology · 2021Review
- Differential glucose metabolism in weight restored women with anorexia nervosa.Psychoneuroendocrinology · 2019Article
- Brain Glucose-Sensing Mechanism and Energy Homeostasis.Molecular neurobiology · 2019Review
- Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass.European journal of clinical nutrition · 2017Review
- Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior.Scientific reports · 2017Article
- Obesity-induced hepatic steatosis is mediated by endoplasmic reticulum stress in the subfornical organ of the brain.JCI insight · 2017Article
- Glucose-Sensing in the Reward System.Frontiers in neuroscience · 2017Review
- RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat.Scientific reports · 2016Article
- The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.Diabetes · 2016Article
- Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis.Frontiers in neuroscience · 2016Review
- Central Amino Acid Sensing in the Control of Feeding Behavior.Frontiers in endocrinology · 2016Review
- Nutrient-sensing mechanisms and pathways.Nature · 2015Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
It is increasingly apparent that the brain plays a central role in metabolic homeostasis, including the maintenance of blood glucose. This is achieved by various efferent pathways from the brain to periphery, which help control hepatic glucose flux and perhaps insulin-stimulated insulin secretion. Also, critically important for the brain given its dependence on a constant supply of glucose as a fuel--emergency counter-regulatory responses are triggered by the brain if blood glucose starts to fall. To exert these control functions, the brain needs to detect rapidly and accurately changes in blood glucose. In this review, we summarize some of the mechanisms postulated to play a role in this and examine the potential role of the low-affinity hexokinase, glucokinase, in the brain as a key part of some of this sensing. We also discuss how these processes may become altered in diabetes and related metabolic diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.