ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2015
Effect of urban vs. rural residence on the association between atopy and wheeze in Latin America: findings from a case-control analysis.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Understanding and controlling asthma in Latin America: A review of recent research informed by the SCAALA programme.Clinical and translational allergy · 2023Review
- α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgGThe Journal of allergy and clinical immunology · 2021Article
- A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020Article
- Whipworm and roundworm infections.Nature reviews. Disease primers · 2020Review
- Soil-transmitted helminth parasites and allergy: Observations from Ecuador.Parasite immunology · 2019Review
- Classification of Wheezing Children in Rural Bangladesh by Intensity ofJournal of immunology research · 2019Article
- Hygiene practices: Are they protective factors for eczema symptoms?Immunity, inflammation and disease · 2018Article
- Urban vs rural residency and allergy prevalence among adult women: Iowa Women's Health Study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Modulation of Allergic Reactivity in Humans Is Dependent onFrontiers in immunology · 2018Article
- The atopic march: current insights into skin barrier dysfunction and epithelial cell-derived cytokines.Immunological reviews · 2017Review
- Meat Intake and the Dose of Vitamin BInternational journal of tryptophan research : IJTR · 2017Review
- Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice.European clinical respiratory journal · 2017Review
- A life without worms.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2017Review
- Effects of poor hygiene on cytokine phenotypes in children in the tropics.The World Allergy Organization journal · 2016Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Allergens, sources, particles, and molecules: Why do we make IgE responses?Allergology international : official journal of the Japanese Society of Allergology · 2015Review
- Risk factors for acute asthma in tropical America: a case-control study in the City of Esmeraldas, Ecuador.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2015Article
- The allergy epidemics: 1870-2010.The Journal of allergy and clinical immunology · 2015Review
- Effects of environment on human cytokine responses during childhood in the tropics: role of urban versus rural residence.The World Allergy Organization journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 5 countries.
Funding
Abstract
backgroundThe association between atopy and asthma is attenuated in non-affluent populations, an effect that may be explained by childhood infections such as geohelminths.
objectiveTo investigate the association between atopy and wheeze in schoolchildren living in urban and rural areas of Ecuador and examine the effects of geohelminths on this association.
methodsWe performed nested case-control studies among comparable populations of schoolchildren living in rural communities and urban neighbourhoods in the Province of Esmeraldas, Ecuador. We detected geohelminths in stool samples, measured recent wheeze and environmental exposures by parental questionnaire, and atopy by specific IgE (sIgE) and skin prick test (SPT) reactivity to aeroallergens.
resultsAtopy, particularly sIgE to house dust mite (HDM), was more strongly associated with recent wheeze in urban than rural schoolchildren: (urban, adj. OR 5.19, 95% CI 3.37-8.00, P < 0.0001; rural, adj. OR 1.81, 95%CI 1.09-2.99, P = 0.02; interaction, P < 0.001). The population fractions of wheeze attributable to atopy were approximately two-fold greater in urban schoolchildren: SPT to any allergen (urban 23.5% vs. rural 10.1%), SPT to HDM (urban 18.5% vs. rural 9.6%), and anti-HDM IgE (urban 26.5% vs. rural 10.5%), while anti-Ascaris IgE was related to wheeze in a high proportion of rural (49.7%) and urban (35.4%) children. The association between atopy and recent wheeze was attenuated by markers of geohelminth infections.
conclusionsOur data suggest that urban residence modifies the association between HDM atopy and recent wheeze, and this effect is explained partly by geohelminth infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.