ArticleNMR in biomedicine2014
Characterization of diffuse fibrosis in the failing human heart via diffusion tensor imaging and quantitative histological validation.
Article in NMR in biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 63 citations in OpenAlex.
- Microstructural disease and hypoperfusion in dilated cardiomyopathy underpin midwall septal fibrosis.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2026Article
- Outlier detection in cardiac diffusion tensor imaging: Shot rejection or robust fitting?Medical image analysis · 2025Article
- Myocardial disarray and fibrosis across hypertrophic cardiomyopathy stages associate with ECG markers of arrhythmic risk.European heart journal. Cardiovascular Imaging · 2025Article
- Multi-center investigation of cardiac diffusion tensor imaging in healthy volunteers by the Society of Cardiovascular Magnetic Resonance Cardiac Diffusion Special Interest Group NETwork (SIGNET).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025Observational
- Diffusion-tensor magnetic resonance imaging as a non-invasive assessment of extracellular matrix remodeling in lumbar paravertebral muscles of rats with sarcopenia.BMC musculoskeletal disorders · 2024Article
- Cardiac structure discontinuities revealed by ex-vivo microstructural characterization. A focus on the basal inferoseptal left ventricle region.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Pathophysiology of LV Remodeling Following STEMI: A Longitudinal Diffusion Tensor CMR Study.JACC. Cardiovascular imaging · 2023Article
- The comparison of diffusion tensor imaging in human hearts between 1.5 T and 3.0 T.BMC medical imaging · 2023Article
- Validation of cardiac diffusion tensor imaging sequences: A multicentre test-retest phantom study.NMR in biomedicine · 2022Article
- Phenotyping hypertrophic cardiomyopathy using cardiac diffusion magnetic resonance imaging: the relationship between microvascular dysfunction and microstructural changes.European heart journal. Cardiovascular Imaging · 2022Article
- From dissection of fibrotic pathways to assessment of drug interactions to reduce cardiac fibrosis and heart failure.Current research in pharmacology and drug discovery · 2021Review
- Myofiber organization in the failing systemic right ventricle.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- Regional variations in ex-vivo diffusion tensor anisotropy are associated with cardiomyocyte remodeling in rats after left ventricular pressure overload.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- Thyroid-Associated Orbitopathy: Evaluating Microstructural Changes of Extraocular Muscles and Optic Nerves Using Readout-Segmented Echo-Planar Imaging-Based Diffusion Tensor Imaging.Korean journal of radiology · 2020Article
- Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Identification of Myocardial Disarray in Patients With Hypertrophic Cardiomyopathy and Ventricular Arrhythmias.Journal of the American College of Cardiology · 2019Article
- Quantifying precision in cardiac diffusion tensor imaging with second-order motion-compensated convex optimized diffusion encoding.Magnetic resonance in medicine · 2018Article
- Fibrosis quantification in Hypertensive Heart Disease with LVH and Non-LVH: Findings from T1 mapping and Contrast-free Cardiac Diffusion-weighted imaging.Scientific reports · 2017Article
- In vivo diffusion-tensor MRI of the human heart on a 3 tesla clinical scanner: An optimized second order (M2) motion compensated diffusion-preparation approach.Magnetic resonance in medicine · 2016Article
- Orientation dependence of microcirculation-induced diffusion signal in anisotropic tissues.Magnetic resonance in medicine · 2016Article
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Non-invasive imaging techniques are highly desirable as an alternative to conventional biopsy for the characterization of the remodeling of tissues associated with disease progression, including end-stage heart failure. Cardiac diffusion tensor imaging (DTI) has become an established method for the characterization of myocardial microstructure. However, the relationships between diffuse myocardial fibrosis, which is a key biomarker for staging and treatment planning of the failing heart, and measured DTI parameters have yet to be investigated systematically. In this study, DTI was performed on left ventricular specimens collected from patients with chronic end-stage heart failure as a result of idiopathic dilated cardiomyopathy (n = 14) and from normal donors (n = 5). Scalar DTI parameters, including fractional anisotropy (FA) and mean (MD), primary (D1 ), secondary (D2 ) and tertiary (D3 ) diffusivities, were correlated with collagen content measured by digital microscopy. Compared with hearts from normal subjects, the FA in failing hearts decreased by 22%, whereas the MD, D2 and D3 increased by 12%, 14% and 24%, respectively (P < 0.01). No significant change was detected for D1 between the two groups. Furthermore, significant correlation was observed between the DTI scalar indices and quantitative histological measurements of collagen (i.e. fibrosis). Pearson's correlation coefficients (r) between collagen content and FA, MD, D2 and D3 were -0.51, 0.59, 0.56 and 0.62 (P < 0.05), respectively. The correlation between D1 and collagen content was not significant (r = 0.46, P = 0.05). Computational modeling analysis indicated that the behaviors of the DTI parameters as a function of the degree of fibrosis were well explained by compartmental exchange between myocardial and collagenous tissues. Combined, these findings suggest that scalar DTI parameters can be used as metrics for the non-invasive assessment of diffuse fibrosis in failing hearts.
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