ArticleBiological psychiatry2016
Transcriptome Analysis of the Human Striatum in Tourette Syndrome.
Article in Biological psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 3 of them syntheses that pooled it.
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Who cites it
119 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Profiles of Proinflammatory Cytokines and T Cells in Patients With Tourette Syndrome: A Meta-Analysis.Frontiers in immunology · 2022Pooled it
- Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review.Translational psychiatry · 2021Pooled it
- Altered expression of histamine signaling genes in autism spectrum disorder.Translational psychiatry · 2017Pooled it
- Article
- Clinical Profile and Plasma Vitamin B6 Levels in Children with Tourette Syndrome: A Case-control Study.Indian journal of psychological medicine · 2026Article
- Tourette disorder features pervasive neuronal and glial transcriptional remodeling in the dorsolateral prefrontal cortex.bioRxiv : the preprint server for biology · 2026Article
- Altered striosome-matrix distribution and activity of striatal cholinergic interneurons in a model of autism-linked repetitive behaviors.Molecular psychiatry · 2026Article
- Mechanisms of Changma Xifeng tablet in alleviating Tourette syndrome via modulation of neurotransmitters, inflammatory responses, and metabolic pathways.Frontiers in psychiatry · 2026Article
- Elucidating the material basis and therapeutic mechanisms of Shaoma Zhijing granules for tourette syndrome by UPLC/Q-TOF-MS and multiple models.Metabolic brain disease · 2025Article
- Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study.JCPP advances · 2025Article
- Tic-related behaviors in Celsr3 mutant mice are contributed by alterations of striatal DMolecular psychiatry · 2025Article
- Interneuron Loss and Microglia Activation by Transcriptome Analyses in the Basal Ganglia of Tourette Disorder.Biological psychiatry · 2025Article
- Clonidine Ameliorates Neuroinflammation in the Rat Model of Tourette Syndrome.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Neuroinflammation and pathways that contribute to tourette syndrome.Italian journal of pediatrics · 2025Review
- Maternal autoimmune diseases and the risk of tics and Tourette's disorder in offspring: insights from Taiwan's real-world data.Frontiers in pediatrics · 2025Article
- Yinhua Gouteng decoction alleviates tic disorder symptoms by modulating neuro-inflammation in a rat model.Frontiers in immunology · 2025Article
- The volatile oil ofFrontiers in pharmacology · 2025Article
- Abnormalities of iron homeostasis and the dopaminergic system in Tourette syndrome revealed by 7T MRI and PET.Brain communications · 2025Article
- Convergent molecular signatures across eating disorders and obsessive-compulsive disorder in the human brain.medRxiv : the preprint server for health sciences · 2024Article
- Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome.Brain, behavior, and immunity · 2024Article
59 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
backgroundGenome-wide association studies have not revealed any risk-conferring common genetic variants in Tourette syndrome (TS), requiring the adoption of alternative approaches to investigate the pathophysiology of this disorder.
methodsWe obtained the basal ganglia transcriptome by RNA sequencing in the caudate and putamen of nine TS and nine matched normal control subjects.
resultsWe found 309 downregulated and 822 upregulated genes in the caudate and putamen (striatum) of TS individuals. Using data-driven gene network analysis, we identified 17 gene coexpression modules associated with TS. The top-scoring downregulated module in TS was enriched in striatal interneuron transcripts, which was confirmed by decreased numbers of cholinergic and gamma-aminobutyric acidergic interneurons by immunohistochemistry in the same regions. The top-scoring upregulated module was enriched in immune-related genes, consistent with activation of microglia in patients' striatum. Genes implicated by copy number variants in TS were enriched in the interneuron module, as well as in a protocadherin module. Module clustering revealed that the interneuron module was correlated with a neuronal metabolism module.
conclusionsConvergence of differential expression, network analyses, and module clustering, together with copy number variants implicated in TS, strongly implicates disrupted interneuron signaling in the pathophysiology of severe TS and suggests that metabolic alterations may be linked to their death or dysfunction.
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