ReviewBiomechanics and modeling in mechanobiology2015
Use it or lose it: multiscale skeletal muscle adaptation to mechanical stimuli.
Review in Biomechanics and modeling in mechanobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed.
- Effect ofFrontiers in sports and active living · 2026Trial
- Early Shortening of Wrist Flexor Muscles Coincides With Poor Recovery After Stroke.Neurorehabilitation and neural repair · 2018Trial
- Contribution of Neuromuscular Factors to Quadriceps Asymmetry After Anterior Cruciate Ligament Reconstruction.Journal of athletic training · 2018Trial
- Musculoskeletal Pain and Hip Muscle Length Among Undergraduates: A Longitudinal Study of 1 Year.Medicina (Kaunas, Lithuania) · 2026Article
- Mechanochemical modeling of exercise-induced skeletal muscle hypertrophy.PLoS computational biology · 2026Article
- The hidden architecture of back pain: ultrasound-based lumbar multifidus pennation angle analysis - a cross-sectional pilot study.BMC musculoskeletal disorders · 2026Article
- Muscle morphology and function following a transfemoral amputation: A systematic review.Canadian prosthetics & orthotics journal · 2026Review
- Harnessing Nonlinear Mechanics to Transform Medical Diagnostics.Applied mechanics reviews · 2025Article
- A forward-engineered, muscle-driven soft robotic swimmer.Science advances · 2025Article
- Multi-scale modeling and simulation of skeletal muscles with different fatigue degrees based on microphysiology.Scientific reports · 2025Article
- Predictive control of musculotendon loads across fast and slow-twitch muscles in a simulated system with parallel actuation.Wearable technologies · 2025Article
- The Structure, Function, and Adaptation of Lower-Limb Aponeuroses: Implications for Myo-Aponeurotic Injury.Sports medicine - open · 2024Review
- Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats.Skeletal muscle · 2024Article
- Discussing Conflicting Explanatory Approaches in Flexibility Training Under Consideration of Physiology: A Narrative Review.Sports medicine (Auckland, N.Z.) · 2024Review
- The Biomechanics of Musculoskeletal Tissues during Activities of Daily Living: Dynamic Assessment Using Quantitative Transmission-Mode Ultrasound Techniques.Healthcare (Basel, Switzerland) · 2024Review
- Habitually wearing high heels may improve user walking economy in any footwear.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- A novel computational framework for the estimation of internal musculoskeletal loading and muscle adaptation in hypogravity.Frontiers in physiology · 2024Article
- Role of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching.Science advances · 2023Article
- Review
- Spatiotemporal single-cell tracking analysis in 3D tissues to reveal heterogeneous cellular response to mechanical stimuli.Science advances · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Skeletal muscle undergoes continuous turnover to adapt to changes in its mechanical environment. Overload increases muscle mass, whereas underload decreases muscle mass. These changes are correlated with, and enabled by, structural alterations across the molecular, subcellular, cellular, tissue, and organ scales. Despite extensive research on muscle adaptation at the individual scales, the interaction of the underlying mechanisms across the scales remains poorly understood. Here, we present a thorough review and a broad classification of multiscale muscle adaptation in response to a variety of mechanical stimuli. From this classification, we suggest that a mathematical model for skeletal muscle adaptation should include the four major stimuli, overstretch, understretch, overload, and underload, and the five key players in skeletal muscle adaptation, myosin heavy chain isoform, serial sarcomere number, parallel sarcomere number, pennation angle, and extracellular matrix composition. Including this information in multiscale computational models of muscle will shape our understanding of the interacting mechanisms of skeletal muscle adaptation across the scales. Ultimately, this will allow us to rationalize the design of exercise and rehabilitation programs, and improve the long-term success of interventional treatment in musculoskeletal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.