Evidence map›Paper›PMID 25199917›Full record

ArticleMolecular psychiatry2014

Environmental risk, Oxytocin Receptor Gene (OXTR) methylation and youth callous-unemotional traits: a 13-year longitudinal study.

C A M Cecil, L J Lysenko, S R Jaffee, J-B Pingault, R G Smith, C L Relton, G Woodward, W McArdle, J Mill, E D Barker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 7 pooled it
21.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 7 syntheses or guidelines pooled it, 186 citations in OpenAlex.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

C A M CecilInstitute of Psychiatry, King's College London, London, UK.ORCID 0000000223895922
L J LysenkoInstitute of Psychiatry, King's College London, London, UK.
S R JaffeeDepartment of Psychology, University of Pennsylvania, Philadelphia, PA, USA.
J-B Pingault1] Institute of Psychiatry, King's College London, London, UK [2] Division of Psychology and Language Sciences, University College London, London, UK.
R G SmithInstitute of Psychiatry, King's College London, London, UK.
C L ReltonMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
G WoodwardMedical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
W McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
J Mill1] Institute of Psychiatry, King's College London, London, UK [2] Exeter Medical School, Exeter University, Exeter, UK.
E D BarkerInstitute of Psychiatry, King's College London, London, UK.
King's College London · GBUniversity of Bristol · GBUniversity of Pennsylvania · US

Funding

Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Medical Research Council 092731Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/2NICHD NIH HHS R01 HD068437NICHD NIH HHS R01HD068437Wellcome Trust 102215
6 · The paper itself

Abstract

Youth with high callous-unemotional traits (CU) are at risk for early-onset and persistent conduct problems. Research suggests that there may be different developmental pathways to CU (genetic/constitutional vs environmental), and that the absence or presence of co-occurring internalizing problems is a key marker. However, it is unclear whether such a distinction is valid. Intermediate phenotypes such as DNA methylation, an epigenetic modification regulating gene expression, may help to clarify etiological pathways. This is the first study to examine prospective inter-relationships between environmental risk (prenatal/postnatal) and DNA methylation (birth, age 7 and 9) in the prediction of CU (age 13), for youth low vs high in internalizing problems. We focused on DNA methylation in the vicinity of the oxytocin receptor (OXTR) gene as it has been previously implicated in CU. Participants were 84 youth with early-onset and persistent conduct problems drawn from the Avon Longitudinal Study of Parents and Children. For youth with low internalizing problems (46%), we found that (i) OXTR methylation at birth associated with higher CU (age 13) as well as decreased experience of victimization during childhood (evocative epigenetic-environment correlation; birth-age 7), (ii) higher prenatal parental risks (maternal psychopathology, criminal behaviors, substance use) associated with higher OXTR methylation at birth and (iii) OXTR methylation levels were more stable across time (birth-age 9). In contrast, for youth with high internalizing problems, CU were associated with prenatal risks of an interpersonal nature (that is, intimate partner violence, family conflict) but not OXTR methylation. Findings support the existence of distinct developmental pathways to CU.

Indexed as

Social EnvironmentChildConduct DisorderCrime VictimsDNA MethylationFamilyFemaleHumansInfant, NewbornLongitudinal StudiesMalePregnancyProspective StudiesReceptors, OxytocinRiskOXTR protein, humanReceptors, Oxytocin

Identifiers

PMID25199917
PMCPMC4231290
OpenAlexW2030983312

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.