Evidence map›Paper›PMID 25199912›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2015

Comparative effects of light or heavy resistance power training for improving lower extremity power and physical performance in mobility-limited older adults.

Kieran F Reid, Kimberly I Martin, Gheorghe Doros, David J Clark, Cynthia Hau, Carolynn Patten, Edward M Phillips, Walter R Frontera, Roger A Fielding

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04762342 (Power Training in Older Multiple Sclerosis Patients), which is not on this map. Cited by 50 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 7 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04762342 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Power Training in Older Multiple Sclerosis Patients

TypeinterventionalSponsorUniversity of AarhusRan2020 to 2024Enrolled60ConditionsMultiple Sclerosis, Sclerosis, Demyelinating Autoimmune Diseases, CNS, Autoimmune Diseases of the Nervous SystemArmsPower training
3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 7 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
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  3. Pooled it
  4. Guideline
  5. Approaches to Assessment of Muscle Mass and Myosteatosis on Computed Tomography: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
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  12. Trial
  13. What is a Clinically Meaningful Improvement in Leg-Extensor Power for Mobility-limited Older Adults?The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
    Trial
  14. Trial
  15. Trial
  16. Article
  17. Review
  18. Article
  19. Review
  20. Prevention of Sarcopenia.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Kieran F ReidNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts. Department of Clinical Medicine, Trinity College Dublin, Dublin, Ireland.
Kimberly I MartinNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
Gheorghe DorosDepartment of Biostatistics, Boston University School of Public Health, Massachusetts.
David J ClarkBrain Rehabilitation Research Center, Malcom Randall VA Medical Center and Department of Aging and Geriatric Research, University of Florida, Gainesville.
Cynthia HauNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts.
Carolynn PattenBrain Rehabilitation Research Center, Malcom Randall VA Medical Center and Department of Physical Therapy, University of Florida, Gainesville, Florida.
Edward M PhillipsNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts. Department of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, Massachusetts.
Walter R FronteraDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, Massachusetts. Department of Physiology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. Department of Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, Tennessee.
Roger A FieldingNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts. roger.fielding@tufts.edu.
Tufts University · USUniversity of Florida · USBoston University · USSpaulding Rehabilitation Hospital · USTrinity College Dublin · IE

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ravi Jasuja · 2008 to 2026
$23.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Improving Outcome Measurement for Medical Rehabilitaiton Clinical TrialsR24HD065688 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JETTE, ALAN MAURICE, ZAFONTE, ROSS DENNIS · 2010 to 2014
$3.9M
LOWER EXTREMITY MUSCLE POWER AND FUNCTION IN THE ELDERLYR01AG018844 · NIA · TUFTS UNIVERSITY BOSTON · PI FIELDING, ROGER A. · 2001 to 2009
$3.0M
NIA NIH HHS 1P30AG031679NIA NIH HHS AG18844NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG031679NIA NIH HHS R01 AG018844NICHD NIH HHS 1R24HD065688-01A1
6 · The paper itself

Abstract

backgroundWe compared the effects of two uniquely different lower extremity power training interventions on changes in muscle power, physical performance, neuromuscular activation, and muscle cross sectional area in mobility-limited older adults.

methodsFifty-two subjects (78±5 years, short physical performance battery score: 8.1±1) were randomized to either 16 weeks of progressive high velocity resistance training performed at low external resistance (40% of the 1-repetition maximum [1-RM] [LO]) or high external resistance (70% of 1RM [HI]). Both groups completed three sets of leg and knee extension exercises at maximum voluntary velocity, two times per week. Neuromuscular activation was assessed using surface electromyography and muscle cross sectional area (CSA) was measured using computed tomography.

resultsAt 16 weeks, LO and HI exhibited significant and similar within-group increases of leg extensor peak power (~34% vs ~42%), strength (~13% vs ~19%), and SPPB score (1.4±0.3 vs 1.8±0.3 units), respectively (all P < .03). Improvements in neuromuscular activation occurred in LO (P = .03) while small gains in mid-thigh muscle CSA were detected in LO (1.6%, P = .35) and HI (2.1%, P = .17). No significant between-group differences were evident for any measured parameters (all P > .25).

conclusionsHigh velocity resistance training with low external resistance yields similar improvements in muscle power and physical performance compared to training with high external resistance in mobility-limited elders. These findings may have important implications for optimizing exercise interventions for older adults with mobility limitations.

Indexed as

Lower ExtremityMobility LimitationResistance TrainingAgedAged, 80 and overElectromyographyFemaleHumansIsometric ContractionMaleMuscle StrengthQuadriceps MuscleSingle-Blind MethodTomography, X-Ray Computedexercise interventionshigh-velocity resistance training.Mobility limitationsmuscle power

Identifiers

PMID25199912
PMCPMC4351393
OpenAlexW2125326148

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.