Evidence map›Paper›PMID 25199856›Full record

Trial reportNitric oxide : biology and chemistry2015

Effect of acute dietary nitrate intake on maximal knee extensor speed and power in healthy men and women.

Andrew R Coggan, Joshua L Leibowitz, Ana Kadkhodayan, Deepak P Thomas, Sujata Ramamurthy, Catherine Anderson Spearie, Suzanne Waller, Marsha Farmer, Linda R Peterson

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nitric oxide : biology and chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 90 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 11 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03513302 nacompletednot on this mapstarted 2019, after this paper: background citation

Dietary Nitrate and Muscle Power With Aging

TypeinterventionalSponsorIndiana UniversityRan2019 to 2022Enrolled47ConditionsAging, SarcopeniaArmsplacebo, nitrate
NCT03595774 phase1completednot on this mapstarted 2018, after this paper: background citation

Dose-response Effect of Dietary Nitrate on Muscle Function in Older Individuals

TypeinterventionalSponsorIndiana UniversityRan2018 to 2021Enrolled13ConditionsAging, SarcopeniaArmsBeet root juice
3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 11 syntheses or guidelines pooled it, 153 citations in OpenAlex.

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  5. The Effects of Dietary Nitrate Supplementation on Explosive Exercise Performance: A Systematic Review.International journal of environmental research and public health · 2022
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  15. Dietary nitrate and muscle contractile function in women: effect of menstrual cycle phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2026
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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Andrew R CogganCardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: coggana@mir.wustl.edu.
Joshua L LeibowitzCardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ana KadkhodayanCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Deepak P ThomasCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Sujata RamamurthyCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Catherine Anderson SpearieCenter for Applied Research Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
Suzanne WallerCenter for Applied Research Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marsha FarmerCardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Linda R PetersonCardiovascular Imaging Laboratory, Division of Radiological Sciences, Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000448
6 · The paper itself

Abstract

Nitric oxide (NO) has been demonstrated to enhance the maximal shortening velocity and maximal power of rodent muscle. Dietary nitrate (NO3(-)) intake has been demonstrated to increase NO bioavailability in humans. We therefore hypothesized that acute dietary NO3(-) intake (in the form of a concentrated beetroot juice (BRJ) supplement) would improve muscle speed and power in humans. To test this hypothesis, healthy men and women (n = 12; age = 22-50 y) were studied using a randomized, double-blind, placebo-controlled crossover design. After an overnight fast, subjects ingested 140 mL of BRJ either containing or devoid of 11.2 mmol of NO3(-). After 2 h, knee extensor contractile function was assessed using a Biodex 4 isokinetic dynamometer. Breath NO levels were also measured periodically using a Niox Mino analyzer as a biomarker of whole-body NO production. No significant changes in breath NO were observed in the placebo trial, whereas breath NO rose by 61% (P < 0.001; effect size = 1.19) after dietary NO3(-) intake. This was accompanied by a 4% (P < 0.01; effect size = 0.74) increase in peak knee extensor power at the highest angular velocity tested (i.e., 6.28 rad/s). Calculated maximal knee extensor power was therefore greater (i.e., 7.90 ± 0.59 vs. 7.44 ± 0.53 W/kg; P < 0.05; effect size = 0.63) after dietary NO3(-) intake, as was the calculated maximal velocity (i.e., 14.5 ± 0.9 vs. 13.1 ± 0.8 rad/s; P < 0.05; effect size = 0.67). No differences in muscle function were observed during 50 consecutive knee extensions performed at 3.14 rad/s. We conclude that acute dietary NO3(-) intake increases whole-body NO production and muscle speed and power in healthy men and women.

Indexed as

AdultBiological AvailabilityDietary SupplementsFemaleHumansKnee JointMaleMiddle AgedMuscle ContractionMuscle FatigueMuscle, SkeletalMuscle StrengthNitratesNitric OxideTorqueYoung AdultNitratesNitric OxideDietary nitrateHumansIsokineticMuscle powerNitric oxide

Identifiers

PMID25199856
PMCPMC4362985
OpenAlexW1979118907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.