SynthesisAddiction science & clinical practice2014
Review of the assessment and management of neonatal abstinence syndrome.
Synthesis in Addiction science & clinical practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- Opioid treatment for opioid withdrawal in newborn infants.The Cochrane database of systematic reviews · 2021Pooled it
- Sedatives for opioid withdrawal in newborn infants.The Cochrane database of systematic reviews · 2021Pooled it
- Outcome reporting in neonates experiencing withdrawal following opioid exposure in pregnancy: a systematic review.Trials · 2020Pooled it
- Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version.German medical science : GMS e-journal · 2015Guideline
- Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal.The New England journal of medicine · 2023Trial
- The effect of prenatal alcohol co-exposure on neonatal abstinence syndrome in infants born to mothers in opioid maintenance treatment.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2016Trial
- Physiologic dysregulation in newborns with prenatal opioid exposure: Cardiac, respiratory and movement activity.Neurotoxicology and teratologyTrial
- Regional Evidence on Neonatal Abstinence Syndrome: Association Between Finnegan Score Severity and Laboratory Findings in a Tertiary NICU.Healthcare (Basel, Switzerland) · 2026Article
- Modeling heart rate patterns to quantify neonatal opioid withdrawal syndrome.Pediatric research · 2026Article
- Hospital Care for Pregnant Persons With OUD Review.American journal of medicine open · 2025Review
- A Roadmap to Improved Quality Outcomes in Neonates Exposed to Illegally Manufactured Fentanyl.Journal of pediatrics. Clinical practice · 2025Article
- Managing newborns at risk for neonatal abstinence syndrome (NAS)/neonatal opioid withdrawal syndrome (NOWS): Updates and emerging best practices.Paediatrics & child health · 2025Review
- La prise en charge des nouveau-nés à risque de syndrome d'abstinence néonatale et de syndrome de sevrage néonatal aux opioïdes : mises à jour et pratiques exemplaires émergentes.Paediatrics & child health · 2025Review
- Is Childcare Availability in Addiction Treatment Associated with County-Level Childcare Prices and Median Income in the United States?Health services insights · 2025Article
- A Systematic Review of Clinical Practice Guidelines for Neonatal Abstinence Syndrome.Children (Basel, Switzerland) · 2023Review
- Global research production in neonatal abstinence syndrome: A bibliometric analysis.World journal of clinical pediatrics · 2022Article
- Prenatal opioid-exposed infant extracellular miRNA signature obtained at birth predicts severity of neonatal opioid withdrawal syndrome.Scientific reports · 2022Article
- Severity of neonatal opioid withdrawal syndrome with prenatal exposure to serotonin reuptake inhibitors.Pediatric research · 2022Article
- Pre-formulation and Stability Study of 20-mcg Clonidine Hydrochloride Pediatric Capsules.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Informing the Development of a Standardized Clinical Definition of Neonatal Abstinence Syndrome: Protocol for a Modified-Delphi Expert Panel.JMIR research protocols · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Neonatal abstinence syndrome (NAS) secondary to in-utero opioid exposure is an increasing problem. Variability in assessment and treatment of NAS has been attributed to the lack of high-quality evidence to guide management of exposed neonates. This systematic review examines available evidence for NAS assessment tools, nonpharmacologic interventions, and pharmacologic management of opioid-exposed infants. There is limited data on the inter-observer reliability of NAS assessment tools due to lack of a standardized approach. In addition, most scales were developed prior to the prevalent use of prescribed prenatal concomitant medications, which can complicate NAS assessment. Nonpharmacologic interventions, particularly breastfeeding, may decrease NAS severity. Opioid medications such as morphine or methadone are recommended as first-line therapy, with phenobarbital or clonidine as second-line adjunctive therapy. Further research is needed to determine best practices for assessment, nonpharmacologic intervention, and pharmacologic management of infants with NAS in order to improve outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.