Evidence map›Paper›PMID 25199782›Full record

ArticleAntimicrobial agents and chemotherapy2014

Clinical and molecular epidemiology of Escherichia coli sequence type 131 among hospitalized patients colonized intestinally with fluoroquinolone-resistant E. coli.

Jennifer H Han, Brian Johnston, Irving Nachamkin, Pam Tolomeo, Warren B Bilker, Xiangqun Mao, Connie Clabots, Ebbing Lautenbach, James R Johnson, CDC Prevention Epicenters Program

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Regional variations in fluoroquinolone non-susceptibility amongAntimicrobial resistance and infection control · 2016
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jennifer H HanDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA jennifer.han@uphs.upenn.edu.
Brian JohnstonMinneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Irving NachamkinDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pam TolomeoCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Warren B BilkerCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Xiangqun MaoCenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Connie ClabotsMinneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Ebbing LautenbachDivision of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
James R JohnsonMinneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota, USA Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
CDC Prevention Epicenters Program

Funding

Mentoring and patient-oriented research in antimicrobial resistanceK24AI080942 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI LAUTENBACH, EBBING · 2009 to 2013
$853k
Carbapenem-Resistant Klebsiella Pneumoniae in Long-Term Acute Care HospitalsK01AI103028 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAN, JENNIFER · 2013 to 2017
$669k
Emergence of E. coli sequence type ST131I01CX000192 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI JOHNSON, JAMES R · 2009 to 2013
–
Gut reservoir of E. coli ST131I01CX000920 · VA · MINNEAPOLIS VA MEDICAL CENTER · PI JOHNSON, JAMES R · 2014 to 2021
–
CSRD VA I01 CX000192CSRD VA I01 CX000920NCEZID CDC HHS U54 CK000163NCEZID CDC HHS U54-CK000163NIAID NIH HHS K01 AI103028NIAID NIH HHS K01-AI103028NIAID NIH HHS K24 AI080942NIAID NIH HHS K24-AI080942
6 · The paper itself

Abstract

This study examined molecular and epidemiologic factors associated with Escherichia coli sequence type 131 (ST131) among hospitalized patients colonized intestinally with fluoroquinolone (FQ)-resistant E. coli between 2002 and 2004. Among 86 patients, 21 (24%) were colonized with ST131. The proportion of ST131 isolates among colonizing isolates increased significantly over time, from 8% in 2002 to 50% in 2004 (P = 0.003). Furthermore, all 19 clonally related isolates were ST131. Future studies should identify potential transmissibility differences between ST131 and non-ST131 strains.

Indexed as

Anti-Bacterial AgentsBacterial Typing TechniquesCarrier ProteinsDNA, BacterialDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsEscherichia coli ProteinsFluoroquinolonesHospitalizationHumansMicrobial Sensitivity TestsMolecular EpidemiologyPolymorphism, Single NucleotideAcrAB-TolC protein, E coliAnti-Bacterial AgentsCarrier ProteinsDNA, BacterialEscherichia coli ProteinsFluoroquinolones

Identifiers

PMID25199782
PMCPMC4249391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.