Evidence map›Paper›PMID 25199652›Full record

ArticleBiological research for nursing2014

A biobehavioral perspective on telomere length and the exposome.

Debra E Lyon, Angela R Starkweather, Alison Montpetit, Victoria Menzies, Nancy Jallo

Open access · greenAbstract read
In one paragraph

Article in Biological research for nursing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Why are there associations between telomere length and behaviour?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Debra E LyonCollege of Nursing, University of Florida, Gainesville, FL, USA delyon@ufl.edu.
Angela R StarkweatherVirginia Commonwealth University, School of Nursing, Richmond, VA, USA.
Alison MontpetitVirginia Commonwealth University, School of Nursing, Richmond, VA, USA.
Victoria MenziesVirginia Commonwealth University, School of Nursing, Richmond, VA, USA.
Nancy JalloVirginia Commonwealth University, School of Nursing, Richmond, VA, USA.
Virginia Commonwealth University · USUniversity of Florida · US

Funding

Epigenetics and Psychoneurologic Symptoms in Women with Breast CancerR01NR012667 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI JACKSON-COOK, COLLEEN K, LYON, DEBRA E · 2010 to 2014
$3.1M
Center of Excellence in Biobehavioral Approaches to Symptom ManagementP30NR011403 · NINR · VIRGINIA COMMONWEALTH UNIVERSITY · PI GRAP, MARY JO · 2009 to 2013
$2.2M
NINR NIH HHS P30 NR011403NINR NIH HHS R01 NR012667
6 · The paper itself

Abstract

A major objective of biobehavioral research is defining the mechanisms that underlie linkages among behavior, biology, health, and disease. The genomic revolution has demonstrated the importance of studying the role of the environment in (epi)genetic mechanisms. The idea that interactions between environment and genetics influence health outcomes is a central concept of the exposome, a measure of environmental exposures throughout a lifetime. Research suggests that telomere length (TL) and biologic factors involved in telomere stability may provide an understanding of the effects of gene-environment interaction on disease risk. Telomeres, thus, have become important biomarkers for aging as well as for stress-related disease. However, incorporating telomeres into biobehavioral research requires consideration of several aspects of the exposome. Internal and external modifiable and nonmodifiable exposures have the potential to influence TL. Future research utilizing the concept of the exposome will provide meaningful findings related to exposure sources as well as dosage and duration across the life span that influence telomere biology and disease occurrence. Such findings can be translated into clinical practice and may provide a basis for personalized disease prevention and treatment approaches.

Indexed as

Environmental ExposureTelomereBehaviorBiomarkersEpigenesis, GeneticHumansBiomarkersbiobehavioralexposometelomere

Identifiers

PMID25199652
PMCPMC5248586
OpenAlexW2329291676

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.