ArticleBMJ (Clinical research ed.)2014
Impact of sepsis on risk of postoperative arterial and venous thromboses: large prospective cohort study.
Article in BMJ (Clinical research ed.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Epidemiology and risk factors for thrombosis in children and newborns: systematic evaluation and meta-analysis.BMC pediatrics · 2023Pooled it
- Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis.Intensive care medicine · 2021Pooled it
- Platelet P2Y12 Inhibitors Reduce Systemic Inflammation and Its Prothrombotic Effects in an Experimental Human Model.Arteriosclerosis, thrombosis, and vascular biology · 2015Trial
- Risk factors and a nomogram model for deep vein thrombosis in critically ill patients with sepsis: a retrospective analysis.Scientific reports · 2025Observational
- Article
- Risk Factors for Postoperative Infections in Severe Traumatic Brain Injury Patients Undergoing Emergency Craniotomy.Therapeutics and clinical risk management · 2025Article
- Continuation of chronic antiplatelet therapy is not associated with increased need for transfusions: a cohort study in critically ill septic patients.BMC anesthesiology · 2024Article
- Risk factors for venous thromboembolism in a single pediatric intensive care unit in China.Thrombosis journal · 2024Article
- Predictors of 30-Day Mortality and Morbidity Following Craniotomy for Traumatic Brain Injury: An ACS NSQIP Database Analysis.Neurotrauma reports · 2024Article
- Association between statin use and acute pulmonary embolism in intensive care unit patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2024Article
- Cardiovascular Events Among Survivors of Sepsis Hospitalization: A Retrospective Cohort Analysis.Journal of the American Heart Association · 2023Article
- Assessing the performance of genetic risk score for stratifying risk of post-sepsis cardiovascular complications.Frontiers in cardiovascular medicine · 2023Article
- Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort study.Intensive care medicine · 2022Article
- Effect of antiplatelet agents onFrontiers in microbiology · 2022Review
- Primary Stroke and Failure-to-Rescue Following Thoracic Endovascular Aortic Aneurysm Repair.Journal of cardiothoracic and vascular anesthesia · 2021Article
- Hypocoagulable Tendency on Thromboelastometry Associated With Severity and Anticoagulation Timing in Pediatric Septic Shock: A Prospective Observational Study.Frontiers in pediatrics · 2021Article
- Post-traumatic pulmonary embolism: incidence, physiopathology, risk factors of early occurrence, and impact outcome. A narrative review.American journal of cardiovascular disease · 2020Review
- Behçet's syndrome as a tool to dissect the mechanisms of thrombo-inflammation: clinical and pathogenetic aspects.Clinical and experimental immunology · 2019Review
- Venous thromboembolism in patients with cancer undergoing surgical exploration.Journal of thrombosis and thrombolysis · 2019Article
- Neutrophil accumulation and NET release contribute to thrombosis in HIT.JCI insight · 2018Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the impact of preoperative sepsis on risk of postoperative arterial and venous thromboses.
designProspective cohort study using the National Surgical Quality Improvement Program database of the American College of Surgeons (ACS-NSQIP).
settingInpatient and outpatient procedures in 374 hospitals of all types across the United States, 2005-12.
participants2,305,380 adults who underwent surgical procedures.
main outcome measuresArterial thrombosis (myocardial infarction or stroke) and venous thrombosis (deep venous thrombosis or pulmonary embolism) in the 30 days after surgery.
resultsAmong all surgical procedures, patients with preoperative systemic inflammatory response syndrome or any sepsis had three times the odds of having an arterial or venous postoperative thrombosis (odds ratio 3.1, 95% confidence interval 3.0 to 3.1). The adjusted odds ratios were 2.7 (2.5 to 2.8) for arterial thrombosis and 3.3 (3.2 to 3.4) for venous thrombosis. The adjusted odds ratios for thrombosis were 2.5 (2.4 to 2.6) in patients with systemic inflammatory response syndrome, 3.3 (3.1 to 3.4) in patients with sepsis, and 5.7 (5.4 to 6.1) in patients with severe sepsis, compared with patients without any systemic inflammation. In patients with preoperative sepsis, both emergency and elective surgical procedures had a twofold increased odds of thrombosis.
conclusionsPreoperative sepsis represents an important independent risk factor for both arterial and venous thromboses. The risk of thrombosis increases with the severity of the inflammatory response and is higher in both emergent and elective surgical procedures. Suspicion of thrombosis should be higher in patients with sepsis who undergo surgery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.