ArticleParasites & vectors2014
Plasma microRNAs are promising novel biomarkers for the early detection of Toxoplasma gondii infection.
Article in Parasites & vectors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases.Journal of extracellular vesicles · 2024Review
- MicroRNA mmu-miR-511-5p: A promising Diagnostic Biomarker in Experimental Toxoplasmosis Using Different Strains and Infective Doses in Mice with Different Immune States Before and After Treatment.Acta parasitologica · 2024Article
- A Systematic Review of Apicomplexa Looking into Epigenetic Pathways and the Opportunity for Novel Therapies.Pathogens (Basel, Switzerland) · 2023Review
- A combined miRNA-piRNA signature in the serum and urine of rabbits infected with Toxoplasma gondii oocysts.Parasites & vectors · 2022Article
- Article
- Parasite-derived microRNAs as a diagnostic biomarker: potential roles, characteristics, and limitations.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2021Review
- microRNA-125b-5p is a promising novel plasma biomarker for alveolar echinococcosis in patients from the southern province of Qinghai.BMC infectious diseases · 2021Article
- The Role of microRNAs in the Infection byFrontiers in cellular and infection microbiology · 2021Review
- Review
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- Impact ofFrontiers in cellular and infection microbiology · 2019Review
- Screening and identification of potential novel biomarker for diagnosis of complicated Plasmodium vivax malaria.Journal of translational medicine · 2018Article
- Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-β signalling pathways.Scientific reports · 2018Article
- Integrated Analysis Reveals That miR-193b, miR-671, and TREM-1 Correlate With a Good Response to Treatment of Human Localized Cutaneous Leishmaniasis Caused byFrontiers in immunology · 2018Article
- Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection.Oncotarget · 2017Article
- Tying malaria and microRNAs: from the biology to future diagnostic perspectives.Malaria journal · 2016Review
- MicroRNAs in the Host-Apicomplexan Parasites Interactions: A Review of Immunopathological Aspects.Frontiers in cellular and infection microbiology · 2016Review
- Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210.Parasites & vectors · 2015Article
- Comparative Expression Profile Analysis of Apoptosis-Related miRNA and Its Target Gene inIranian journal of parasitologyArticle
- Current and Emerging Techniques for Diagnosis of Toxoplasmosis in Pregnancy: A Narrative Review.Iranian journal of parasitologyReview
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicroRNAs (miRNAs) have been shown to be present in plasma, which are remarkably stable, and have been suggested as disease biomarkers. Toxoplasma gondii (T. gondii) is a protozoan parasite that is infective to a wide range of animals and human beings. Previous studies have found that the parasite generated a large number of miRNAs during proliferation and it is known that the spectrum of miRNA expression in the infected hosts is pathogen-specific. To date, there are no reports regarding the application of microRNAs as biomarkers for the early detection of T. gondii infection.
methodsIn this study, we investigated the expression patterns of 414 murine miRNAs and tested their expression levels in the plasma after T. gondii infection by real-time PCR, with an ultimate purpose of identifying infection-related miRNAs. Three miRNAs in particular, exhibiting prominently elevated expressions, were further validated in a large number of infected mice. The Toxoplasma infection-specific miRNAs were confirmed by comparing their expression levels with those of mice infected with Plasmodium berghei, P. yoelii, P. chabaudi, Cryptosporidium parvum, Mouse hepatitis virus, and Staphylococcus aureus.
resultsAmong the 414 miRNA candidates identified by a real-time PCR array, 71 were found to be up-regulated in the plasma of T. gondii infected mice. Three of those miRNAs (mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p) were prominently expressed in mice infected by both the RH and ME49 strains of T. gondii. Additionally, the elevated expression of these miRNAs was Toxoplasma-specific.
conclusionsThe levels of the three miRNAs, mmu-miR-712-3p, mmu-miR-511-5p and mmu-miR-217-5p miRNAs, were found specifically up-regulated in plasma of mice after T. gondii infection.
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