Evidence map›Paper›PMID 25199063›Full record

ReviewClinical nuclear medicine2014

Brain PET in the diagnosis of Alzheimer's disease.

Charles Marcus, Esther Mena, Rathan M Subramaniam

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinical nuclear medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05614310 (Early Detection Of Alzheimer's Disease With GlucoCEST MRI), which is not on this map. Cited by 183 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05614310 recruitingnot on this mapstarted 2022, after this paper: background citation

Early Detection Of Alzheimer's Disease With GlucoCEST MRI: A Feasibility Study.

TypeobservationalSponsorUniversity of AberdeenRan2022 to 2025Enrolled60ConditionsAlzheimer DiseaseArmsMagnetic Resonance Imaging (MRI), Blood Glucose Assessment, Positron Emission Tomography (PET), Cognitive Assessment
3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 3 syntheses or guidelines pooled it, 371 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Astrocyte reactivity across the AD continuum measured by [European journal of nuclear medicine and molecular imaging · 2026
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  17. Adaptive Integration of Incomplete Multimodal 3D Neuroimaging for Alzheimer's Prediction and Biomarker Discovery.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2026
    Article
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  19. Article
  20. Review

123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Charles Marcus*Post Doctorate Research Fellow in the Russell H. Morgan, Department of Radiology and Radiological Sciences at Johns Hopkins University in Baltimore, MD; †Nuclear Medicine Resident in the Russell H. Morgan, Department ofRadiology and Radiological Sciences at Johns Hopkins University in Baltimore, MD; ‡Associate Professor in the Russell H. Morgan, Department of Radiology and Radiological Sciences, Department of Oncology, Department of Otolaryngology-Head and Neck Surgery at Johns Hopkins School of Medicine, and the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Esther Mena
Rathan M Subramaniam
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
NCI NIH HHS P30 CA006973
6 · The paper itself

Abstract

objectivesThe aim of this article was to review the current role of brain PET in the diagnosis of Alzheimer dementia. The characteristic patterns of glucose metabolism on brain FDG-PET can help in differentiating Alzheimer's disease from other causes of dementia such as frontotemporal dementia and dementia of Lewy body. Amyloid brain PET may exclude significant amyloid deposition and thus Alzheimer's disease in appropriate clinical setting.

conclusionsFDG-PET and amyloid PET imaging are valuable in the assessment of patients with Alzheimer's disease.

Indexed as

Positron-Emission TomographyAlzheimer DiseaseBrainCognitive DysfunctionFrontotemporal DementiaHumansLewy Body DiseaseRadiopharmaceuticalsRadiopharmaceuticals

Identifiers

PMID25199063
PMCPMC4332800
OpenAlexW2317490759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.