ArticleJournal of biomedical optics2014
Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Hyperspectral imaging for tumor resection guidance in surgery: a systematic review of preclinical and clinical studies.Journal of biomedical optics · 2025Pooled it
- A systematic review on intra-arterial cerebral infusions of chemotherapeutics in the treatment of glioblastoma multiforme: The state-of-the-art.Frontiers in oncology · 2022Pooled it
- Strategies for Improved Intra-arterial Treatments Targeting Brain Tumors: a Systematic Review.Frontiers in oncology · 2020Pooled it
- Real-Time Structural Illumination with Hyperspectral Images: A Tunable Projection-Capture Synchronizer for Three-Phase Demodulation on Embedded Heterogeneous Computing Platforms.Sensors (Basel, Switzerland) · 2026Article
- Training generative adversarial networks for optical property mapping using synthetic image data.Biomedical optics express · 2022Article
- Early stage dental caries detection using near infrared spatial frequency domain imaging.Scientific reports · 2021Article
- Dual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring.Biomedical optics express · 2021Article
- Hyperspectral imaging in the spatial frequency domain with a supercontinuum source.Journal of biomedical optics · 2019Article
- Spatial frequency domain imaging in 2019: principles, applications, and perspectives.Journal of biomedical optics · 2019Review
- Light scattering methods for tissue diagnosis.Optica · 2019Article
- Microvascular imaging of the skin.Physics in medicine and biology · 2019Review
- Review of structured light in diffuse optical imaging.Journal of biomedical optics · 2018Review
- Hyperspectral imaging solutions for brain tissue metabolic and hemodynamic monitoring: past, current and future developments.Journal of optics (2010) · 2018Review
- Optical property uncertainty estimates for spatial frequency domain imaging.Biomedical optics express · 2018Article
- High-speed spatial frequency domain imaging of rat cortex detects dynamic optical and physiological properties following cardiac arrest and resuscitation.Neurophotonics · 2017Article
- Diffuse Optical Spectroscopy and Imaging to Detect and Quantify Adipose Tissue Browning.Scientific reports · 2017Article
- Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model.Biomedical optics express · 2016Article
- Noninvasive assessment of hemodynamic and brain metabolism parameters following closed head injury in a mouse model by comparative diffuse optical reflectance approaches.Neurophotonics · 2016Article
- Three-dimensional printed optical phantoms with customized absorption and scattering properties.Biomedical optics express · 2015Article
- Near-infrared spectroscopy integrated catheter for characterization of myocardial tissues: preliminary demonstrations to radiofrequency ablation therapy for atrial fibrillation.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We present an application of spatial frequency-domain imaging (SFDI) to the wide-field imaging of drug delivery to brain tissue. Measurements were compared with values obtained by a previously validated variation of diffuse reflectance spectroscopy, the method of optical pharmacokinetics (OP). We demonstrate a crosscorrelation between the two methods for absorption extraction and drug concentration determination in both experimental tissue phantoms and freshly extracted rodent brain tissue. These methods were first used to assess intra-arterial (IA) delivery of cationic liposomes to brain tissue in Sprague Dawley rats under transient cerebral hypoperfusion. Results were found to be in agreement with previously published experimental data and pharmacokinetic models of IA drug delivery. We then applied the same scheme to evaluate IA mitoxantrone delivery to glioma-bearing rats. Good correlation was seen between OP and SFDI determined concentrations taken from normal and tumor averaged sites. This study shows the feasibility of mapping drug/tracer distributions and encourages the use of SFDI for spatial imaging of tissues for drug/tracer-tagged carrier deposition and pharmacokinetic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.