ArticleJournal of pediatric gastroenterology and nutrition2015
Novel risk factors for recurrent Clostridium difficile infection in children.
Article in Journal of pediatric gastroenterology and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Comparison of pediatric and adult antibiotic-associated diarrhea and Clostridium difficile infections.World journal of gastroenterology · 2016Pooled it
- Double-Blind, Placebo-Controlled Study of Bezlotoxumab in Children Receiving Antibacterial Treatment for Clostridioides difficile Infection (MODIFY III).Journal of the Pediatric Infectious Diseases Society · 2023Trial
- Analysis of clinical characteristics and risk factors of recurrentFrontiers in pediatrics · 2025Article
- Review
- Antimicrobial Resistance ofInfection and drug resistance · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
- Article
- Fecal Microbiota Transplantation for Clostridioides difficile Infection in Immunocompromised Pediatric Patients.Journal of pediatric gastroenterology and nutrition · 2023Article
- Efficacy and Safety of Fecal Microbiota Transplantation in Treatment ofMicroorganisms · 2022Review
- Fecal Microbiota Transplantation and Microbial Therapeutics for the Treatment of Clostridioides difficile Infection in Pediatric Patients.Journal of the Pediatric Infectious Diseases Society · 2021Review
- Clostridioides difficile and the Microbiota Early in Life.Journal of the Pediatric Infectious Diseases Society · 2021Review
- Two-step Testing for Clostridioides Difficile is Inadequate in Differentiating Infection From Colonization in Children.Journal of pediatric gastroenterology and nutrition · 2021Article
- Bacterial Gut Microbiota and Infections During Early Childhood.Frontiers in microbiology · 2021Review
- A novel probiotic therapeutic in a murine model ofGut microbes · 2020Article
- Multi-organism gastrointestinal polymerase chain reaction positivity among pediatric transplant vs non-transplant populations: A single-center experience.Pediatric transplantation · 2020Article
- Efficacy of Fecal Microbiota Transplantation for Clostridium difficile Infection in Children.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020Article
- Recurrent community-acquired Clostridium(Clostridioides)difficile infection in Serbianchildren.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Article
- An Infectious Diseases Perspective on Fecal Microbiota Transplantation for Clostridioides difficile Infection in Children.Journal of the Pediatric Infectious Diseases Society · 2019Review
- Intensity of Therapy for Malignancy and Risk for Recurrent and Complicated Clostridium difficile Infection in Children.Journal of pediatric hematology/oncology · 2019Article
- Gut Microbiota Modulation for Multidrug-Resistant Organism Decolonization: Present and Future Perspectives.Frontiers in microbiology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesClostridium difficile, a common cause of antibiotic-associated diarrhea, has been reported to recur in high rates in adults. The rates and risk factors for recurrent C difficile infection (rCDI) in children have not been well established.
methodsWe conducted a retrospective cohort study of 186 pediatric patients seen at a tertiary care referral center for a 5-year period diagnosed as having a primary C difficile infection. Children with recurrent disease, defined as return of symptoms of C difficile infection and positive testing ≤60 days after the completion of therapy, were compared with children who did not experience an episode of recurrence.
resultsOf the 186 pediatric patients included in this study, 41 (22%) experienced rCDI. On univariable analysis, factors significantly associated with rCDI included malignancy, recent hospitalization, recent surgery, antibiotic use, number of antibiotic exposures by class, acid blocker use, immunosuppressant use, and hospital-acquired disease. On multivariable analysis, malignancy (odds ratio [OR] 3.39, 95% confidence interval [CI] 1.52-7.85), recent surgery (OR 2.40, 95% CI 1.05-5.52), and the number of antibiotic exposures by class (OR 1.33, 95% CI 1.01-1.75) were significantly associated with recurrent disease in children.
conclusionsThe rate of rCDI in children was 22%. Recurrence was significantly associated with the risk factors of malignancy, recent surgery, and the number of antibiotic exposures by class.
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