ArticleOrganic letters2014
Synthesis of substituted 2-aminoimidazoles via Pd-catalyzed alkyne carboamination reactions. Application to the synthesis of preclathridine natural products.
Article in Organic letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Selective Synthesis of Unsaturated Imines via [pyACS catalysis · 2025Article
- Synthesis of heteroatom-containing pyrrolidine derivatives based on Ti(O-RSC advances · 2020Article
- Pd-Catalyzed C-C, C-N, and C-O Bond-Forming Difunctionalization Reactions of Alkenes Bearing Tethered Aryl/Alkenyl Triflates.Israel journal of chemistry · 2020Article
- Catalytic Alkyne Arylation Using Traceless Directing Groups.Angewandte Chemie (International ed. in English) · 2018Article
- Regioselective Base-Mediated Cyclizations of Mono-N-acylpropargylguanidines.The Journal of organic chemistry · 2017Article
- Synthesis of Cyclic Guanidines Bearing N-Arylsulfonyl and N-Cyano Protecting Groups via Pd-Catalyzed Alkene Carboamination Reactions.Organic letters · 2017Article
- Recent Developments in Pd(0)-Catalyzed Alkene Carboheterofunctionalization Reactions.Asian journal of organic chemistry · 2017Article
- Total synthesis and cytotoxicity of Leucetta alkaloids.Bioorganic & medicinal chemistry · 2017Article
- Ti-Catalyzed Multicomponent Oxidative Carboamination of Alkynes with Alkenes and Diazenes.Journal of the American Chemical Society · 2016Article
- An Expeditious and Greener Synthesis of 2-Aminoimidazoles in Deep Eutectic Solvents.Molecules (Basel, Switzerland) · 2016Article
- Synthesis of Cyclic Guanidines via Silver-Catalyzed Intramolecular Alkene Hydroamination Reactions of N-Allylguanidines.Organic letters · 2016Article
- Palladium-Catalyzed Alkene Carboamination Reactions of Electron-Poor Nitrogen Nucleophiles.Advanced synthesis & catalysis · 2015Article
- Studies Towards theEuropean journal of organic chemistry · 2015Article
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3 authors.
Funding
Abstract
A new method for the synthesis of 2-aminoimidazole products is described. The heterocyclic products are generated in good yields via Pd-catalyzed carboamination reactions of N-propargyl guanidines and aryl triflates. This methodology generates both a C-N and C-C bond during the annulation step and facilitates the rapid construction of 2-aminoimidazole products with different aryl groups. The utility of this methodology was demonstrated in the total synthesis of preclathridine A, preclathridine B, and dorimidazole B from a single intermediate.
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