Trial reportPloS one2014
A dietary-wide association study (DWAS) of environmental metal exposure in US children and adults.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Food-Source Patterns and Serum Trace-Metal Biomarkers in the SPES Population Biomonitoring Study, Campania, Italy.Journal of xenobiotics · 2026Article
- Linking soil-metal concentrations with children's blood and urine biomarkers in Syracuse, NY.Environmental research · 2025Article
- Associations between follicular fluid trace elements and ovarian response during in vitro fertilization.Environmental research · 2024Article
- Evaluation of carcinogenic risk of heavy metals due to consumption of rice in Southwestern Iran.Toxicology reports · 2024Article
- Integrating Data Across Multiple Sites in the Northeastern United States to Examine Associations Between a Prenatal Metal Mixture and Child Cognition.American journal of epidemiology · 2024Article
- Heavy Metal and Rice in Gluten-Free Diets: Are They a Risk?Nutrients · 2023Review
- Accumulation of blood chromium and cobalt in the participants with metal objects: findings from the 2015 to 2018 National Health and Nutrition Examination Survey (NHANES).BMC geriatrics · 2023Article
- Article
- Dietary Exposure to Toxic Elements and the Health of Young Children: Methodological Considerations and Data Needs.The Journal of nutrition · 2022Article
- Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort.Epigenetics · 2022Article
- Prenatal metal(loid) mixtures and birth weight for gestational age: A pooled analysis of three cohorts participating in the ECHO program.Environment international · 2022Article
- Determination of the Physicochemical Quality of Groundwater and its Potential Health Risk for Drinking in Oromia, Ethiopia.Environmental health insights · 2022Article
- Bioinformatics Investigations of Universal Stress Proteins from Mercury-MethylatingMicroorganisms · 2021Article
- Diet and erythrocyte metal concentrations in early pregnancy-cross-sectional analysis in Project Viva.The American journal of clinical nutrition · 2021Article
- Trace Element Analysis in Whole Blood and Plasma for Reference Levels in a Selected Queensland Population, Australia.International journal of environmental research and public health · 2021Article
- Total blood mercury and its determinants in New Zealand children and adults.Journal of exposure science & environmental epidemiology · 2021Article
- Prenatal Metal Mixtures and Birth Weight for Gestational Age in a Predominately Lower-Income Hispanic Pregnancy Cohort in Los Angeles.Environmental health perspectives · 2020Article
- Dietary contributions to increased background lead, mercury, and cadmium in 9-11 Year old children: Accounting for racial differences.Environmental research · 2020Article
- Seafood, wine, rice, vegetables, and other food items associated with mercury biomarkers among seafood and non-seafood consumers: NHANES 2011-2012.Journal of exposure science & environmental epidemiology · 2020Article
- Assessing the contributions of metals in environmental media to exposure biomarkers in a region of ferroalloy industry.Journal of exposure science & environmental epidemiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundA growing body of evidence suggests that exposure to toxic metals occurs through diet but few studies have comprehensively examined dietary sources of exposure in US populations. PURPOSE: Our goal was to perform a novel dietary-wide association study (DWAS) to identify specific dietary sources of lead, cadmium, mercury, and arsenic exposure in US children and adults.
methodsWe combined data from the National Health and Nutrition Examination Survey with data from the US Department of Agriculture's Food Intakes Converted to Retail Commodities Database to examine associations between 49 different foods and environmental metal exposure. Using blood and urinary biomarkers for lead, cadmium, mercury, and arsenic, we compared sources of dietary exposure among children to that of adults.
resultsDiet accounted for more of the variation in mercury and arsenic than lead and cadmium. For instance we estimate 4.5% of the variation of mercury among children and 10.5% among adults is explained by diet. We identified a previously unrecognized association between rice consumption and mercury in a US study population--adjusted for other dietary sources such as seafood, an increase of 10 g/day of rice consumption was associated with a 4.8% (95% CI: 3.6, 5.2) increase in blood mercury concentration. Associations between diet and metal exposure were similar among children and adults, and we recapitulated other known dietary sources of exposure.
conclusionUtilizing this combination of data sources, this approach has the potential to identify and monitor dietary sources of metal exposure in the US population.
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