Evidence map›Paper›PMID 25198262›Full record

ArticleObstetrics and gynecology2014

Association of age and parity with intrauterine device expulsion.

Tessa Madden, Colleen McNicholas, Qiuhong Zhao, Gina M Secura, David L Eisenberg, Jeffrey F Peipert

Open access · greenAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
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  11. Five-year Contraceptive Use of 52-mg Levonorgestrel Releasing Intrauterine System in Young Women, Menstrual Patterns, and New Contraceptive Choice.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023
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  18. Contraception for AdolescentsJournal of clinical research in pediatric endocrinology · 2020
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  19. Feasibility and Safety of IUD Insertion by Mid-Level Providers in Sub-Saharan Africa.International perspectives on sexual and reproductive health · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Tessa MaddenDivision of Clinical Research, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.
Colleen McNicholas
Qiuhong Zhao
Gina M Secura
David L Eisenberg
Jeffrey F Peipert
Washington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesTL1TR000449 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$2.5M
Reproductive Epidemiology Training Program at Washington University in St. LouisT32HD055172 · NICHD · WASHINGTON UNIVERSITY · PI MADDEN, TESSA · 2009 to 2018
$2.5M
EVALUATION AND TESTING OF A DECISION SUPPORT AID IN CONTRACEPTIVE DECISION MAKINGK23HD070979 · NICHD · WASHINGTON UNIVERSITY · PI MADDEN, TESSA · 2012 to 2014
$367k
NCATS NIH HHS TL1 TR000449NCATS NIH HHS UL1 TR000448NICHD NIH HHS K23 HD070979NICHD NIH HHS K23HD070979NICHD NIH HHS T32 HD055172NICHD NIH HHS T32HD055172
6 · The paper itself

Abstract

objectiveTo investigate whether age 14 to 19 years and nulliparity are associated with expulsion of levonorgestrel and copper intrauterine devices (IUDs).

methodsThis was a planned secondary analysis of the Contraceptive CHOICE Project. We used Kaplan-Meier survival analysis to estimate expulsion rates for the first levonorgestrel or copper IUD received during study participation. Cox proportional hazards regression models were used to investigate baseline characteristics associated with expulsion.

resultsA total of 5,403 females were included; 4,219 (78%) used the levonorgestrel IUD and 1,184 (22%) used the copper IUD. There were 432 initial expulsions reported. The 36-month cumulative expulsion rate was 10.2 per 100 IUD users and did not vary by IUD type (levonorgestrel IUD 10.1 compared with copper IUD 10.7, P=.99). In the bivariate analysis, multiple characteristics including age, nulliparity, immediate postabortion insertion, and heavy menses were associated with expulsion. The cumulative rate of expulsion was lower in nulliparous women compared with parous women (8.4 compared with 11.4; P<.001) and higher in females aged 14 to 19 compared with older women (18.8 compared with 9.3; P<.001). After adjusting for confounders and stratifying by IUD type, the hazard ratio of expulsion for females aged 14 to 19 years was 2.26 (95% confidence interval [CI] 1.68-3.06) for the levonorgestrel IUD and 3.06 (95% CI 1.75-5.33) for the copper IUD. Compared to parous levonorgestrel IUD users, expulsion was lower for nulliparous levonorgestrel IUD users (adjusted hazard ratio 0.59, 95% CI 0.44-0.78).

conclusionIUD expulsions were not increased in nulliparous females. More expulsions were observed in females aged 14 to 19 compared with older women regardless of parity or IUD type. LEVEL OF EVIDENCE: : II.

Indexed as

ParityAdolescentAdultAge FactorsAnalysis of VarianceChi-Square DistributionCohort StudiesFemaleFollow-Up StudiesHumansIntrauterine Device ExpulsionIntrauterine Devices, CopperIntrauterine Devices, MedicatedKaplan-Meier EstimateLevonorgestrelMiddle AgedLevonorgestrel

Identifiers

PMID25198262
PMCPMC4172535
OpenAlexW1966567302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.