ArticleJournal of musculoskeletal & neuronal interactions2014
Bone-muscle indices as risk factors for fractures in men: the Osteoporotic Fractures in Men (MrOS) Study.
Article in Journal of musculoskeletal & neuronal interactions, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Comparison of Peripheral Imaging Technologies for Bone and Muscle Quantification: a Mixed Methods Clinical Review.Current osteoporosis reports · 2016Pooled it
- Trabecular texture and paraspinal muscle characteristics for prediction of first vertebral fracture: a QCT analysis from the AGES cohort.Frontiers in endocrinology · 2025Article
- Article
- Next-generation imaging of the skeletal system and its blood supply.Nature reviews. Rheumatology · 2019Review
- Quantitative analysis of skeletal muscle by computed tomography imaging-State of the art.Journal of orthopaedic translation · 2018Review
- Associations Between Lean Mass, Muscle Strength and Power, and Skeletal Size, Density and Strength in Older Men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Osteoporosis in men: findings from the Osteoporotic Fractures in Men Study (MrOS).Therapeutic advances in musculoskeletal disease · 2016Review
- Analysis of the independent power of age-related, anthropometric and mechanical factors as determinants of the structure of radius and tibia in normal adults. A pQCT study.Journal of musculoskeletal & neuronal interactions · 2015Article
- Peripheral quantitative computed tomography-derived muscle density and peripheral magnetic resonance imaging-derived muscle adiposity: precision and associations with fragility fractures in women.Journal of musculoskeletal & neuronal interactions · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
objectiveTo assess bone-muscle (B-M) indices as risk factors for incident fractures in men.
methodsParticipants of the Osteoporotic Fractures in Men (MrOS) Study completed a peripheral quantitative computed tomography scan at 66% of their tibial length. Bone macrostructure, estimates of bone strength, and muscle area were computed. Areal bone mineral density (aBMD) and body composition were assessed with dual-energy X-ray absorptiometry. Four year incident non-spine and clinical vertebral fractures were ascertained. B-M indices were expressed as bone-to-muscle ratios for: strength, mass and area. Discriminative power and hazards ratios (HR) for fractures were reported.
resultsIn 1163 men (age: 77.2±5.2 years, body mass index (BMI): 28.0±4.0 kg/m(2), 4.1±0.9 follow-up years, 7.7% of men ⋝1 fracture), B-M indices were smaller in fractured men except for bending and areal indices. Smaller B-M indices were associated with increased fracture risk (HR: 1.30 to 1.74) independent of age and BMI. Strength and mass indices remained significant after accounting for lumbar spine but not total hip aBMD. However, aBMD correlated significantly with B-M indices.
conclusionMass and bending B-M indices are risk factors for fractures in men, but may not improve fracture risk prediction beyond that provided by total hip aBMD.
Indexed as
Identifiers
25198219PMC4197057What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.