Evidence map›Paper›PMID 25198176›Full record

ArticlePloS one2014

Aging differentially affects the loss of neuronal dendritic spine, neuroinflammation and memory impairment at rats after surgery.

Yuan Le, Shuli Liu, Mingchao Peng, Chang Tan, Qin Liao, Kaiming Duan, Wen Ouyang, Jianbin Tong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 69 citations in OpenAlex.

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  14. Establishment and assessment of postoperative cognitive impairment in intermittent hypoxia rats.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuan LeDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Shuli LiuDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Mingchao PengDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Chang TanDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Qin LiaoDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Kaiming DuanDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Wen OuyangDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Jianbin TongDepartment of Anesthesiology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China; Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Central South University · CNThird Xiangya Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is known that age is an important factor for postoperative cognitive dysfunction (POCD) and the patients with POCD suffer from the impairment of multiple brain regions and multiple brain functions. However currently animal studies of POCD mainly focus on hippocampus region, therefore in this study we performed partial hepatectomy in young adult and aged rats to test the questions (1) whether POCD in animals involves other brain areas besides hippocampus; (2) how age influences POCD of young adult and aged animals. We found that (1) in young adult rats, the memory was not significantly affected (P>0.05) 1d, 3d and 7d after partial hepatectomy, but was significantly impaired (p<0.001) in aged rats 1d and 3d post-surgery; (2) in young adult rats, the surgery did not significantly affect the densities of dendritic spines of neurons at CA1, dentate gyrus (DG) and cingulate cortex (P>0.05, respectively) 1d and 3d post-surgery, but the spine densities at CA1 and DG of aged rats were significant reduced 1d and 3d post-surgery (p<0.001, respectively), however this didn't happen at cingulate cortex (P>0.05); (3) In young adult rats, surgery didn't affect the activation of microglia and levels of TNF-α and IL-1β at hippocampus (P>0.05), but significantly activated microglia and increased levels of TNF-α and IL-1β at hippocampus of aged rats (P<0.05). Our data suggest that (1) partial hepatectomy-induced POCD mainly involves hippocampus impairments, and (2) differential loss of neuronal dendritic spines and neuroinflammation at hippocampus are most likely the mechanism for the formation of POCD in aged rats.

Indexed as

AgingAnimalsDendritic SpinesFemaleHepatectomyInflammationMemory DisordersRatsRats, Sprague-Dawley

Identifiers

PMID25198176
PMCPMC4157839
OpenAlexW2070603987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.