Trial reportSleep2014
A randomized, double crossover study to investigate the influence of saline infusion on sleep apnea severity in men.
Trial report in Sleep, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Society of Anesthesia and Sleep Medicine Guidelines on Preoperative Screening and Assessment of Adult Patients With Obstructive Sleep Apnea.Anesthesia and analgesia · 2016Guideline
- Heart Rate Variability Responses of Individuals With and Without Saline-Induced Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Trial
- Relationship of Fluid Accumulation in the Neck to Sleep Structure in Men during Daytime Sleep.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Trial
- The Effect of Simulated Obstructive Apneas on Mechanical Characteristics of Lower Airways in Individuals with Asthma.Annals of biomedical engineering · 2024Article
- Anatomical Basis of Obstructive Sleep Apnoea: A Review of Randomized Controlled Trials.Cureus · 2023Review
- Perioperative trends in neck and leg fluid volume in surgical patients: a prospective observational proof-of-concept study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Observational
- Article
- A pilot study in men to show the effects of postural fluid shifts on the severity of obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2020Article
- Surgical management of obstructive sleep apnoea: A position statement of the Australasian Sleep AssociationRespirology (Carlton, Vic.) · 2020Article
- Reduced genioglossus muscle activity caused by fluid overload in anesthetized rats.Physiological reports · 2020Article
- Targeting Endotypic Traits with Medications for the Pharmacological Treatment of Obstructive Sleep Apnea. A Review of the Current Literature.Journal of clinical medicine · 2019Review
- Effects of Increased Pharyngeal Tissue Mass Due to Fluid Accumulation in the Neck on the Acoustic Features of Snoring Sounds in Men.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.Frontiers in pharmacology · 2018Article
- A novel approach for acoustic estimation of neck fluid volume between men and women.Medical & biological engineering & computing · 2018Article
- Fluid Redistribution in Sleep Apnea: Therapeutic Implications in Edematous States.Frontiers in medicine · 2017Review
- Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer.Journal of thoracic disease · 2016Review
- A Subject-Specific Acoustic Model of the Upper Airway for Snoring Sounds Generation.Scientific reports · 2016Article
- Review
- Management of Hypertension in Obstructive Sleep Apnea.Current cardiology reports · 2015Review
- Salt Content in IV Fluids Given Intraoperatively May Influence Postoperative OSA Severity.Sleep · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
STUDY
objectivesObstructive sleep apnea (OSA) is commoner in patients with fluid-retaining states than in those without fluid retention, in men than in women, and worsens with aging. In men, OSA severity is related to the amount of fluid shifting out of the legs overnight, but a cause-effect relationship is not established. Our objective was to test the hypothesis that mimicking fluid overload during sleep would increase severity of OSA more in older (≥ 40 years) than in younger men (< 40 years).
designRandomized, single-blind, double crossover study.
settingResearch sleep laboratory. PATIENTS OR
participantsSeven older and 10 younger men with non-severe or no sleep apnea, matched for body mass index.
interventionsDuring the control arm, normal saline was infused to keep the vein open. During intervention, subjects received an intravenous bolus of normal saline (22 mL/kg body weight) after sleep onset while they were wearing compression stockings to prevent fluid accumulation in the legs. MEASUREMENTS AND
resultsCompared to younger men, infusion of similar amounts of saline in older men caused a greater increase in neck circumference (P < 0.05) and in the AHI (32.2 ± 22.1 vs. 2.2 ± 7.1, P = 0.002).
conclusionsOlder men are more susceptible to the adverse effects of intravenous fluid loading on obstructive sleep apnea severity than younger men. This may be due to age-related differences in the amount of fluid accumulating in the neck or upper airway collapsibility in response to intravenous fluid loading. These possibilities remain to be tested in future studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.