ArticleOxidative medicine and cellular longevity2014
Short-term diet and moderate exercise in young overweight men modulate cardiocyte and hepatocarcinoma survival by oxidative stress.
Article in Oxidative medicine and cellular longevity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 412 citations in OpenAlex.
- Dietary Temperature's Influence on Energy Balance in Humans: Protocol for a Randomized Controlled Trial and Crossover Design.JMIR research protocols · 2023Article
- MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats.Frontiers in endocrinology · 2022Article
- Lifestyle and Hepatocellular Carcinoma What Is the Evidence and Prevention Recommendations.Cancers · 2021Review
- Transcranial Magnetic Stimulation as a Tool to Investigate Motor Cortex Excitability in Sport.Brain sciences · 2021Review
- Review
- Aerobic Exercise and Metabolic Syndrome: The Role of Sympathetic Activity and the Redox System.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Neuropsychiatric and Behavioral Involvement in AAS Abusers. A Literature Review.Medicina (Kaunas, Lithuania) · 2019Review
- Ameliorative effect of Silybin on bisphenol A induced oxidative stress, cell proliferation and steroid hormones oxidation in HepG2 cell cultures.Scientific reports · 2019Article
- The Effect of a Competitive Futsal Match on T Lymphocyte Surface Receptor Signaling and Functions.Frontiers in physiology · 2018Article
- Beneficial Effects of Elderly Tailored Mediterranean Diet on the Proteasomal Proteolysis.Frontiers in physiology · 2018Article
- Article
- Role of Sex Hormones in the Control of Vegetative and Metabolic Functions of Middle-Aged Women.Frontiers in physiology · 2017Article
- Osteopontin: Relation between Adipose Tissue and Bone Homeostasis.Stem cells international · 2017Review
- Basal Forebrain Cholinergic System and Orexin Neurons: Effects on Attention.Frontiers in behavioral neuroscience · 2017Review
- Quality of life in overweight (obese) and normal-weight women with polycystic ovary syndrome.Patient preference and adherence · 2017Article
- Role of Autonomic Nervous System and Orexinergic System on Adipose Tissue.Frontiers in physiology · 2017Review
- Exercise Modifies the Gut Microbiota with Positive Health Effects.Oxidative medicine and cellular longevity · 2017Review
- Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies.Frontiers in neurology · 2017Review
- Orexin System: The Key for a Healthy Life.Frontiers in physiology · 2017Review
- Improvement of Bone Physiology and Life Quality Due to Association of Risedronate and Anastrozole.Frontiers in pharmacology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was designed to evaluate the effects of diet lifestyle on extending lifespan and reducing liver cancer risk. Young overweight men (n = 20), without metabolic syndrome, were placed in a 3-week residential program on a low-fat diet and moderate aerobic exercise. In each subject, pre- and postintervention fasting blood were collected for evaluating levels of serum lipids, and oxidative stress markers. Using subject sera and cardiomyocyte (H9C2) culture systems, we measured heat shock protein 27 and 90 expression, lipid accumulation, and oxidative stress marker levels. After 3-weeks of diet, significant reductions (P < 0.05) in body mass index, serum lipids and lipid ratios, and oxidative markers were recorded. In vitro, we observed that the addition of postintervention sera increased H9C2 cell number and reduced HSP27 and 90 expression, mitochondrial superoxide anion, and lipid accumulation with a parallel increase in nitric oxide (NO) production (all P < 0.01). At the same time, postintervention sera decreased human liver hepatocellular carcinoma cell line (HepG-2) proliferation, lipid accumulation, oxidative stress, and extracellular-signal-regulated kinases (ERK1/2) activity. Lifestyle modification in young overweight men, without metabolic syndrome, could ameliorate cardiocyte survival and reduce hepatocellular carcinoma cell proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.