Evidence map›Paper›PMID 25197401›Full record

ArticleInternational journal of clinical and experimental pathology2014

Nodal involvement by marginal zone B-cell lymphoma harboring t(14;22)(q32;q11) involving immunoglobulin heavy chain and light chain lambda as the sole karyotypically recognizable abnormality in a patient with systemic lupus erythematosus.

Ke Li, Rebecca L Johnson, Shiyong Li, John A Thorson, Carolyn M Mulroney, Marie L Dell'Aquila, Huan-You Wang

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PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ke LiDepartment of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA ; Current address: Department of Pathology, University of Utah Salt Lake City, UT 84112 USA.
Rebecca L JohnsonDepartment of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
Shiyong LiDepartment of Pathology, Emory University Atlanta, GA 30322, USA.
John A ThorsonDepartment of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
Carolyn M MulroneyDivision of Hematology, Department of Medicine, University of California San Diego Health System La Jolla, CA 92093, USA.
Marie L Dell'AquilaDepartment of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
Huan-You WangDepartment of Pathology, University of California San Diego Health System La Jolla, CA 92093, USA.
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent non-random balanced chromosomal translocation, usually involving the immunoglobulin heavy chain (IgH) gene or an immunoglobulin light chain gene and a proto-oncogene, which results in the overexpression of the latter under the control of an enhancer or promoter of the former, is a hallmark of many types of non-Hodgkin lymphoma (NHL) of B-cell origin. However, translocations between IgH and the immunoglobulin (Ig) light chain lambda gene (IgL), namely, a t(14;22)(q32;q11), have rarely been described in B-cell NHL. Herein we report the first case of marginal zone B-cell lymphoma harboring a t(14;22)(q32;q11) as its sole genetic abnormality in a patient with a 12-year history of systemic lupus erythematosus (SLE). Other interesting findings of this case include: 1) the neoplastic B-cells lack expression of both surface and cytoplasmic Ig light chain as revealed by flow cytometry and 2) monoclonal rearrangement of Ig light chain kappa (IgK) only due to k-deleting element (kde) recombination event. This case illustrates the necessity of utilizing a multi-modality approach in the diagnosis of B-cell NHL.

Indexed as

AdultChromosomes, Human, Pair 14Chromosomes, Human, Pair 22FemaleFlow CytometryHumansImmunoglobulin Heavy ChainsImmunoglobulin lambda-ChainsImmunohistochemistryIn Situ HybridizationKaryotypingLupus Erythematosus, SystemicLymph NodesLymphoma, B-Cell, Marginal ZoneProto-Oncogene MasTranslocation, GeneticImmunoglobulin Heavy ChainsImmunoglobulin lambda-ChainsMAS1 protein, humanProto-Oncogene MasK-deleting elementmarginal zone B-cell lymphomasystemic lupus erythematosust(14;22)(q32;q11)

Identifiers

PMID25197401
PMCPMC4152091
OpenAlexW1414515222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.