Evidence map›Paper›PMID 25197376›Full record

ArticleInternational journal of clinical and experimental pathology2014

Prognostic significance of astrocyte elevated gene-1 in human astrocytomas.

Zhangxiu He, Meihui He, Chao Wang, Baozhan Xu, Liping Tong, Junming He, Bowen Sun, Lanlan Wei, Ming Chu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhangxiu HeDepartment of Neurosurgery, The First Affiliated Hospital, Harbin Medical University Harbin 150001, China.
Meihui HeDepartment of Microbiology, Harbin Medical University, Immunity and Infection, Pathogenic Biology Key Laboratory in Heilongjiang Province Harbin 150081, China.
Chao WangDepartment of Neurosurgery, The Third Affiliated Hospital, Harbin Medical University Harbin 150001, China.
Baozhan XuDepartment of Neurosurgery, The First Affiliated Hospital, Harbin Medical University Harbin 150001, China.
Liping TongDepartment of Microbiology, Harbin Medical University, Immunity and Infection, Pathogenic Biology Key Laboratory in Heilongjiang Province Harbin 150081, China.
Junming HeDepartment of Microbiology, Harbin Medical University, Immunity and Infection, Pathogenic Biology Key Laboratory in Heilongjiang Province Harbin 150081, China.
Bowen SunDepartment of Microbiology, Harbin Medical University, Immunity and Infection, Pathogenic Biology Key Laboratory in Heilongjiang Province Harbin 150081, China.
Lanlan WeiDepartment of Microbiology, Harbin Medical University, Immunity and Infection, Pathogenic Biology Key Laboratory in Heilongjiang Province Harbin 150081, China.
Ming ChuDepartment of Neurosurgery, The First Affiliated Hospital, Harbin Medical University Harbin 150001, China.
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocyte Elevated Gene-1 (AEG-1) has been proposed as a biomarker for a variety of cancers. This study aimed to investigate the expression of AEG-1 in human astrocytomas and the correlation between AEG-1 expression and clinicopathologic variables of astrocytomas. AEG-1 expression in four pairs of matched astrocytomas tissues and 5 cell lines was detected by immunohistochemical and Western blot analysis. In addition, AEG-1 protein expression was examined by immunohistochemical staining in 204 cases, including 32 normal brain tissues, 80 Low-malignant astrocytomas (LMAs) and 92 High-Malignant astrocytomas (HMAs). AEG-1 expression in 31 LMAs and 29 HMAs samples was detected by RT-PCR and Western blot analysis. We detected AEG-1 expression in normal neurons and glioma cell lines U87, U251 and M059K, but not in normal glial cells. Immunohistochemical analysis showed that 128 of 172 (74.4%) paraffin-embedded archival astrocytomas samples exhibited positive AEG-1 expression. Statistical analysis suggested that higher AEG-1 level was significantly correlated with histological grade of astrocytomas. In addition, AEG-1 mRNA and protein expression was higher in HMAs than in LMAs. AEG-1 expression had no correlation with the gender or age of astrocytoma patients. In summary, our data suggest that AEG-1 may represent a novel prognostic marker for astrocytomas.

Indexed as

AdolescentAdultAgedAged, 80 and overAstrocytomaBiomarkers, TumorBlotting, WesternBrain NeoplasmsCell Adhesion MoleculesChildChild, PreschoolFemaleHumansImmunohistochemistryMaleMembrane ProteinsBiomarkers, TumorCell Adhesion MoleculesMembrane ProteinsMTDH protein, humanRNA-Binding ProteinsAEG-1Astrocytomaprognosis

Identifiers

PMID25197376
PMCPMC4152066
OpenAlexW1466030670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.