SynthesisInternational journal of clinical and experimental pathology2014
Comparison of bone marrow mesenchymal stem cells and core decompression in treatment of osteonecrosis of the femoral head: a meta-analysis.
Synthesis in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- The pandemic is gone but its consequences are here to stay: avascular necrosis following corticosteroids administration for severe COVID-19.Journal of orthopaedic surgery and research · 2024Pooled it
- Efficacy of various core decompression techniques versus non-operative treatment for osteonecrosis of the femoral head: a systemic review and network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2021Pooled it
- Pooled it
- Regenerative therapies increase survivorship of avascular necrosis of the femoral head: a systematic review and meta-analysis.International orthopaedics · 2018Pooled it
- Core decompression versus other joint preserving treatments for osteonecrosis of the femoral head: a meta-analysis.British medical bulletin · 2016Pooled it
- The Role of Cell Therapies for the Treatment of Osteonecrosis of the Femoral Head.The Journal of arthroplasty · 2025Review
- [Femoral head necrosis after femoral neck fracture-A lifelong burden].Unfallchirurgie (Heidelberg, Germany) · 2025Article
- Is core decompression and bone marrow concentrate with demineralized bone matrix and platelet-rich fibrin suitable for treating femoral head osteonecrosis?Journal of hip preservation surgery · 2024Article
- Outcomes of single-incision-augmented core decompression using trochanteric autograft in osteonecrosis of femoral head-a mean 5-year follow-up study.Journal of hip preservation surgery · 2024Article
- Evaluation of Safety and Efficacy of Cell Therapy Based on Osteoblasts Derived from Umbilical Cord Mesenchymal Stem Cells for Osteonecrosis of the Femoral Head: Study Protocol for a Single-Center, Open-Label, Phase I Clinical Trial.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Updating Osteonecrosis of the Femoral Head.Hip & pelvis · 2023Review
- Avascular necrosis of the femoral head: three-dimensional measurement of drilling precision reveals high accuracy and no difference between fluoroscopically controlled core decompression and cancellous bone grafting.Archives of orthopaedic and trauma surgery · 2023Article
- Comparison of two joint-preserving treatments for osteonecrosis of the femoral head: core decompression and core decompression with additional cancellous bone grafting.The Journal of international medical research · 2023Article
- Core decompression for early-stage avascular necrosis of the humeral head: current concepts and techniques.Clinics in shoulder and elbow · 2023Article
- Short-term Follow-up of Autologous Adult Live-Cultured Osteoblasts Implantation in Avascular Necrosis of Femoral Head Secondary to Sickle Cell Anemia-Case Series.Journal of orthopaedic case reports · 2023Article
- Predictors of Core Decompression Success in Patients with Femoral Head Avascular Necrosis.The archives of bone and joint surgery · 2023Article
- The clinical and radiological effectiveness of autologous bone marrow derived osteoblasts (ABMDO) in the management of avascular necrosis of femoral head (ANFH) in sickle cell disease (SCD).Journal of experimental orthopaedics · 2022Article
- Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients.Clinical and translational medicine · 2021Review
- Comparison of cell therapy and other novel adjunctive therapies combined with core decompression for the treatment of osteonecrosis of the femoral head : a systematic review and meta-analysis of 20 studies.Bone & joint research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study aims to compare the clinical efficacy of core decompression (CD) and bone marrow mesenchymal stem cells (BMMSC) on the patients with osteonecrosis of the femoral head (ONFH). A detailed literature search of PubMed, MEDLINE and EMBASE, Springer, Elsevier Science Direct, Cochrane Library and Google scholar for all relevant papers published was performed. Pooled odds ratio (OR) or weighted mean differences (WMD) and 95% confidence interval (CI) were used to evaluate the clinical efficacy of CD and BMMSC with the clinical outcome on the patients with ONFH. A total of 219 hips in 4 studies were indentified in this current meta-analysis. The OR of 2 separate studies consisting of 115 hips (CD group 63 hips; BMMSC group 52 hips) of patients were pooled and suggested BMMSC group had significantly less number of progressed vascularized bone grafting events than CD group (OR = 0.11; 95% CI: 0.03~0.43; P < 0.01). In addition, WMD of other 2 separate studies consisting of 104 hips (CD group 52 hips; BMMSC group 52 hips) in patients were pooled, and significant differences (P < 0.01) in Harris Hip Score (HHS) were observed between these two treatment groups at the end of follow-up study, BMMSC group had significantly better clinical outcome than CD group (WMD = 8.69; 95% CI: 3.76~13.62; P < 0.01). BMMSC may perform a better therapeutic effect than CD on the patients with osteonecrosis of the femoral head.
Indexed as
Identifiers
25197374PMC4152064What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.