ArticleInternational journal of clinical and experimental pathology2014
Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan.
Article in International journal of clinical and experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Subsequent development of cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane in the printing company in Osaka, Japan.Industrial health · 2025Article
- Mini-review: occupational health topics series on the effects of chemicals. Occupational cholangiocarcinoma incident.Journal of occupational health · 2025Review
- Development of intraductal papillary neoplasm of the bile duct in patients with occupational cholangiocarcinoma.Virchows Archiv : an international journal of pathology · 2023Article
- Development of extrahepatic bile ducts and mechanisms of tumorigenesis: Lessons from mouse models.Pathology international · 2022Review
- Transcriptome analysis of human cholangiocytes exposed to carcinogenic 1,2-dichloropropane in the presence of macrophages in vitro.Scientific reports · 2022Article
- The Proportion of Occupationally Related Cholangiocarcinoma: A Tertiary Hospital Study in Northeastern Thailand.Cancers · 2022Article
- Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis.Diagnostic pathology · 2021Article
- Article
- Intraductal Papillary Neoplasm of Bile Duct: Updated Clinicopathological Characteristics and Molecular and Genetic Alterations.Journal of clinical medicine · 2020Review
- Occupational cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane.Annals of gastroenterological surgery · 2018Review
- Safe use of chemicals by professional users and health care specialists.Biomedical reports · 2018Article
- Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma.Oxidative medicine and cellular longevity · 2017Article
- Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents.Surgery today · 2016Article
- Pathological characteristics of intraductal polypoid neoplasms of bile ducts in Thailand.International journal of clinical and experimental pathology · 2015Article
- A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases.Journal of occupational health · 2015Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, cholangiocarcinoma has epidemically developed among young adult workers of a printing company in Japan. Exposure to organic solvents including 1,2-dichloropropane and/or dichloromethane is supposed to be associated with the carcinoma development. The metabolism of dichloromethane proceeds through a Theta-class glutathione S-transferase (GST) T1-1-catalyzed pathway, where its reactive intermediates have been implicated in genotoxicity and carcinogenicity. This study examined features of the carcinogenic process of the cholangiocarcinoma developed in the printing company. Surgically resected specimens of the cholangiocarcinoma cases were analyzed, where all cases were associated with precursor lesions such as biliary intraepithelial neoplasia (BilIN) and/or intraductal papillary neoplasm of the bile duct (IPNB). Immunohistochemical analysis confirmed constitutional expression of GST T1-1 in normal hepatobiliary tract. Immunostaining of γ-H2AX, a marker of DNA double strand break, showed that its expression was significantly increased in foci of BilIN, IPNB and invasive carcinoma as well as in non-neoplastic biliary epithelial cells of the printing company cases when compared to that of control groups. In the printing company cases, immunohistochemical expression of p53 was observed in non-neoplastic biliary epithelial cells and BilIN-1. Mutations of KRAS and GNAS were detected in foci of BilIN in one out of 3 cases of the printing company. These results revealed different carcinogenic process of the printing company cases, suggesting that the exposed organic solvents might act as a carcinogen for biliary epithelial cells by causing DNA damage, thereby contributing to the carcinoma development.
Indexed as
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25197345PMC4152035W26527426What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.