ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2014
The association of body mass index with disease activity and clinical response to combination therapy in patients with rheumatoid arthritis.
Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- A systematic review of the association of obesity with the outcomes of inflammatory rheumatic diseases.Singapore medical journal · 2019Pooled it
- Efficacy of the cardiac glycoside digoxin as an adjunct to csDMARDs in rheumatoid arthritis patients: a randomized, double-blind, placebo-controlled trial.Frontiers in pharmacology · 2024Article
- Metabolic Syndrome and Rheumatoid Arthritis Activity: An Analysis of Clinical, Laboratory, and Ultrasound Parameters.Nutrients · 2023Article
- Correlation between percentage of fat mass and level of disease activity in rheumatoid arthritis.SAGE open medicine · 2022Article
- Challenges in Applying Treat to Target Strategy in Sample of Iraqi Patients with Rheumatoid Arthritis.Mediterranean journal of rheumatology · 2021Article
- Prognostic factors for steroid-free remission in patients with idiopathic inflammatory myopathies: importance of anthropometric measurements.Therapeutic advances in musculoskeletal disease · 2020Article
- The effects of conventional drugs in the treatment of rheumatoid arthritis on the serum lipids.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- Distinct Secretory Activity and Clinical Impact of Subcutaneous Abdominal Adipose Tissue in Women with Rheumatoid Arthritis and Osteoarthritis.Inflammation · 2017Article
- Article
- Body mass index and response to tocilizumab in rheumatoid arthritis: a real life study.Clinical rheumatology · 2016Article
- Effects of aerobic exercise on hematologic indices of women with rheumatoid arthritis: A randomized clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Article
- Impact of Bariatric Surgery on Patients With Rheumatoid Arthritis.Arthritis care & research · 2015Observational
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of obesity in clinical curse of rheumatoid arthritis (RA) is not clear. We investigated the association of obesity and adiposity with disease activity and clinical response to combination therapy in RA patients. MATERIALS AND
methodsActive RA patients with the disease activity score using 28 joint counts (DAS28) > 2.6 were studied. Height, weight, and waist and hip circumferences were measured and body mass index (BMI) and waist to hip ratio were calculated. Patients were treated with methotrexate (7.5 to 10 mg/week) plus hydroxychloroquine (200 to 400 mg/day) and prednisolone (2.5 to 10 mg/day) and were followed by DAS28 for up to 24 weeks.
resultsOne hundred and six patients were studied; age = 48.5 ± 13.8 years, 87.7% female, disease duration = 4.4 years [SE = 0.48]. DAS28 was decreased from 4.5 ± 1.6 to 2.9 ± 1.4 (P < 0.001) after 24 weeks of treatment. Only in patients with disease duration of ≤2 years, BMI (r = -0.415, P = 0.005) and waist circumference (r = -0.296, P = 0.05) were correlated with baseline DAS28. Although BMI (r = -0.337, P = 0.025) and waist circumference (r = -0.315, P = 0.038) were correlated with change in DAS28 after therapy, these correlations were disappeared after controlling for baseline DAS28.
conclusionObesity and adiposity are associated with less severe disease activity in early stage of RA, but are not associated with response to combination therapy with methotrexate plus hydroxychloroquine in RA patients.
Indexed as
Identifiers
25197291PMC4155704W1545188359What OpenQuestion holds
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