ArticleJournal of toxicology2014
Prognostic factors in acute methadone toxicity: a 5-year study.
Article in Journal of toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Incidence of rhabdomyolysis occurrence in psychoactive substances intoxication: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Systematic review of nephrotoxicity of drugs of abuse, 2005-2016.BMC nephrology · 2017Pooled it
- Mortality in methadone poisoning: a decade-long analysis of clinical predictors in an Iranian cohort.International journal of physiology, pathophysiology and pharmacology · 2026Article
- Accidental Methadone Toxicity in a 3-Year-Old Leading to Severe Cerebellitis and Death: A Case Report.Case reports in pediatrics · 2025Article
- The clinico-epidemiological, diagnostic, and therapeutic aspects of methadone poisoning: a registry-based clinical study.Annals of medicine and surgery (2012) · 2024Article
- Evaluating the effect of chronic and continuous use of methadone on the glomerular filtration rate of patients receiving oral methadone (syrup).Frontiers in medicine · 2024Article
- Developing a novel prediction model in opioid overdose using machine learning; a pilot analytical study.Health science reports · 2022Article
- Clinical characteristics and time trends of hospitalized methadone exposures in the United States based on the Toxicology Investigators Consortium (ToxIC) case registry: 2010-2017.BMC pharmacology & toxicology · 2020Article
- Methadone-induced encephalopathy: a case series and literature review.BMC medical imaging · 2020Review
- Stress Cardiomyopathy (Takotsubo syndrome) Following Accidental Methadone Poisoning; Report of Two Pediatric Cases.Archives of academic emergency medicine · 2019Article
- Nephrotoxicity of methadone: a systematic review.SpringerPlus · 2016Review
- Clinical Presentation and the Outcome of Therapy in a Cohort of Patients with Methadone Toxicity in Iran.Materia socio-medica · 2015Article
- Predictive Factors of Treatment Outcomes for Hospital Care in Children with Acute Methadone Poisoning.Journal of research in pharmacy practiceArticle
- Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Delayed or recurrent profound respiratory depression, ventricular dysrhythmias, acute lung injury, and death are the major complications of MTD overdose. We aimed to clarify the prognostic factors in MTD toxicity. Materials and Methods. Retrospectively, medical files of all patients poisoned by MTD and older than 12 years of age who had presented to Loghman Hakim Poison Center between 2007 and 2012 were evaluated. The data was compared between survivors and nonsurvivors. Results. Twenty-eight out of 322 patients died (mortality rate = 8.7%). MTD-related death was higher in patients with acute on chronic toxicity who were on daily dose of MTD and had ingested higher doses (in comparison to those with acute toxicity due to first-time exposure; 13% versus 6%). Renal failure was the most common medical complication related to deaths due to MTD toxicity. Conclusions. Based on previous researches, the most common cause of MTD overdose-related deaths is respiratory impairment; however, in our study, acute renal failure with or without rhabdomyolysis was the main delayed cause of deaths in MTD-poisoned patients. Antidotal therapy, early recognition, and treatment of hemodynamic compromise and rhabdomyolysis can be life-saving in these patients.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.