ArticleInterdisciplinary perspectives on infectious diseases2014
Chest Radiographs for Pediatric TB Diagnosis: Interrater Agreement and Utility.
Article in Interdisciplinary perspectives on infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Diagnostic accuracy of the WHO tuberculosis treatment decision algorithms for children with presumptive tuberculosis: An individual participant data meta-analysis.PLoS medicine · 2025Pooled it
- Screening tests for active pulmonary tuberculosis in children.The Cochrane database of systematic reviews · 2021Pooled it
- Approaches and processes for paediatric chest X-ray classification used in the SHINE TB treatment-shortening trial.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2024Trial
- Computer-aided detection for radiological disease severity classification on chest radiograph in children with intra-thoracic tuberculosis.PLOS global public health · 2026Article
- POCUS Examination of the Mediastinum in Children: A Simplified and Standardized Protocol for Pulmonary Tuberculosis.POCUS journal · 2025Article
- Oral Swab Testing With Xpert MTB/RIF Ultra for the Diagnosis of Tuberculosis in Children Aged <5 Years in Uganda: An Exploratory Interim Analysis of Diagnostic Accuracy in the NOD-pedFEND Cohort.Open forum infectious diseases · 2025Article
- Diagnostic performance of chest radiography for pediatric tuberculosis across high- and low-burden settings.Frontiers in pediatrics · 2025Article
- Diagnostic Accuracy of Cartridge Based Nucleic Acid Amplification Test (CBNAAT) in Stool Samples in Pediatric Tuberculosis: Authors' Reply.Indian journal of pediatrics · 2024Article
- Chest X-Ray-Based Telemedicine Platform for Pediatric Tuberculosis Diagnosis in Low-Resource Settings: Development and Validation Study.JMIR pediatrics and parenting · 2024Article
- Comparison of chest ultrasound features to chest radiography in the diagnosis for pediatric tuberculosis: a cross-sectional study.The Pan African medical journal · 2024Article
- Article
- Public Health Impact and Cost-Effectiveness of Screening for Active Tuberculosis Disease or Infection Among Children in South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Artificial Intelligence in Paediatric Tuberculosis.Pediatric radiology · 2023Review
- Comparison of chest radiograph findings in ambulatory and hospitalized children with pulmonary tuberculosis.Pediatric radiology · 2023Article
- Optimising computer aided detection to identify intra-thoracic tuberculosis on chest x-ray in South African children.PLOS global public health · 2023Article
- Pediatric Tuberculosis Diagnostics: Present and Future.Journal of the Pediatric Infectious Diseases Society · 2022Article
- The Diagnostic Accuracy of Chest Radiographic Features for Pediatric Intrathoracic Tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Article
- Article
- Tuberculosis in Children.Infectious disease clinics of North America · 2022Review
- The Diagnostic Performance of Chest-X-Ray and Erythrocyte Sedimentation Rate in Comparison with GeneXpertRisk management and healthcare policy · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The chest radiograph (CXR) is considered a key diagnostic tool for pediatric tuberculosis (TB) in clinical management and endpoint determination in TB vaccine trials. We set out to compare interrater agreement for TB diagnosis in western Kenya. A pediatric pulmonologist and radiologist (experts), a medical officer (M.O), and four clinical officers (C.Os) with basic training in pediatric CXR reading blindly assessed CXRs of infants who were TB suspects in a cohort study. C.Os had access to clinical findings for patient management. Weighted kappa scores summarized interrater agreement on lymphadenopathy and abnormalities consistent with TB. Sensitivity and specificity of raters were determined using microbiologically confirmed TB as the gold standard (n = 8). A total of 691 radiographs were reviewed. Agreement on abnormalities consistent with TB was poor; k = 0.14 (95% CI: 0.10-0.18) and on lymphadenopathy moderate k = 0.26 (95% CI: 0.18-0.36). M.O [75% (95% CI: 34.9%-96.8%)] and C.Os [63% (95% CI: 24.5%-91.5%)] had high sensitivity for culture confirmed TB. TB vaccine trials utilizing expert agreement on CXR as a nonmicrobiologically confirmed endpoint will have reduced specificity and will underestimate vaccine efficacy. C.Os detected many of the bacteriologically confirmed cases; however, this must be interpreted cautiously as they were unblinded to clinical features.
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Registered trials
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