Protonation equilibria of biologically active ligands in mixed aqueous organic solvents.

Ahmed A El-Sherif, Mohamed M Shoukry, Abeer T Abd Elkarim, Mohammad H Barakat

Abstract readReview

In one paragraph

Review in Bioinorganic chemistry and applications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Monomeric Zn(II) and 3D polymeric Ag(I) complexes with a cationic s-triazine hydrazone-based ligand; synthesis, structure, coordination behavior and biological studies.Scientific reports · 2026
Article
Study of novel bidentate heterocyclic amine-based metal complexes and their biological activities: cytotoxicity and antimicrobial activity evaluation.BMC chemistry · 2023
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ahmed A El-SherifChemistry Department, Faculty of Science, Cairo University, Giza, Egypt ; Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi Arabia.

Mohamed M ShoukryChemistry Department, Faculty of Science, Cairo University, Giza, Egypt ; Department of Chemistry, Faculty of Science, Islamic University, Al-Madinah, Saudi Arabia.

Abeer T Abd ElkarimChemistry Department, Faculty of Science, Cairo University, Giza, Egypt.

Mohammad H BarakatHolding Company for Water and Waste Water, The Reference Laboratory for Drinking Water, Inorganic Laboratory, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The review is mainly concerned with the protonation equilibria of biologically active ligands like amino acids, peptides, DNA constituents, and amino acid esters in nonaqueous media. Equilibrium concentrations of proton-ligand formation as a function of pH were investigated. Also, thermodynamics associated with protonation equilibria were also discussed.

Identifiers

PMID25197267

DOI10.1155/2014/626719

PMCPMC4150405

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.