Evidence map›Paper›PMID 25197204›Full record

ArticleJournal of photochemistry and photobiology. A, Chemistry2014

Photoactive Spatial Proximity Probes for Binding Pairs with Epigenetic Marks.

Roman N Ezhov, Greg A Metzel, Olga A Mukhina, Catherine A Musselman, Tatiana G Kutateladze, Tiffany P Gustafson, Andrei G Kutateladze

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of photochemistry and photobiology. A, Chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roman N EzhovDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO 80208.
Greg A MetzelDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO 80208.
Olga A MukhinaDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO 80208.
Catherine A MusselmanDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045.
Tatiana G KutateladzeDepartment of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045.
Tiffany P GustafsonDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO 80208.
Andrei G KutateladzeDepartment of Chemistry and Biochemistry, University of Denver, Denver, CO 80208.

Funding

Molecular analysis of methylated p53R01GM101664 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI KUTATELADZE, TATIANA G · 2013 to 2016
$1.7M
NIGMS NIH HHS R01 GM101664
6 · The paper itself

Abstract

A new strategy for encoding polypeptide libraries with photolabile tags is developed. The photoassisted assay, based on conditional release of encoding tags only from bound pairs, can differentiate between peptides which have minor differences in a form of post-translational modifications with epigenetic marks. The encoding strategy is fully compatible with automated peptide synthesis. The encoding pendants are compact and do not perturb potential binding interactions.

Indexed as

conditional photorelease of tagsencoded combinatorial libraryepigenetic marksspatial proximity test

Identifiers

PMID25197204
PMCPMC4151188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.