ArticleJournal of Indian Association of Pediatric Surgeons2014
Posterior urethral valve: Prognostic factors and renal outcome.
Article in Journal of Indian Association of Pediatric Surgeons, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Clinical characteristics and kidney outcomes in children with posterior urethral valve: a single-center experience.International urology and nephrology · 2026Article
- Prognostic evaluation of boys with posterior urethral valves using a recursive feature elimination machine learning framework.Frontiers in pediatrics · 2026Article
- Article
- Neglected posterior urethral valve: Cause of irreversible renal damage and end-stage renal disease.Medical journal, Armed Forces India · 2018Article
- Study of prognostic significance of antenatal ultrasonography and renin angiotensin system activation in predicting disease severity in posterior urethral valves.Journal of Indian Association of Pediatric SurgeonsArticle
- Clinical Profile, Management, and Outcome of Posterior Urethral Valves in Children - Experience from a Tertiary Care Hospital.Journal of Indian Association of Pediatric SurgeonsArticle
- Comparing Estimated and Measured Glomerular Filtration Rate in Children with Posterior Urethral Valve.Journal of Indian Association of Pediatric SurgeonsArticle
- Comparison of early neonatal valve ablation with vesicostomy in patient with posterior urethral valve.African journal of paediatric surgery : AJPSArticle
- Role of Urinary Transforming Growth Factor Beta-B1 and Monocyte Chemotactic Protein-1 as Prognostic Biomarkers in Posterior Urethral Valve.Journal of Indian Association of Pediatric SurgeonsArticle
- Does Early Upper Tract Diversion and Delayed Undiversion in Megaureters Secondary to Severe Posterior Urethral Valves Lead to Better Renal Outcomes?Journal of Indian Association of Pediatric SurgeonsArticle
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim was to study the outcome of posterior urethral valve (PUV) cases treated by stepladder protocol and the prognostic factors affecting the outcome. MATERIALS AND
methodsHospital records of all PUV patients treated by stepladder protocol between January 1992 and December 2013 were reviewed. The studied parameters were: Age at presentation, serum creatinine, types of surgical intervention, vesicoureteral reflux (VUR) on initial voiding cystourethrogram (VCUG), renal cortical scars, plasma renin activity (PRA), and glomerular filtration rate (GFR).
resultsOf 396 PUV patients treated during the study period, 152 satisfied study criteria. The age at presentation ranged from 2 days to 15 years (mean 31.3 months). The mean follow-up period was 5 years (range: 2-18 years). Primary endoscopic valve ablation was the most common initial procedure. Chronic renal failure was seen in 42.7% patients at the last follow-up. Serum creatinine at presentation, initial PRA levels, initial GFR, and PRA levels at last follow-up were significant predictors of final renal outcome. Age at presentation (<1 vs. >1 year), presence/absence of VUR on initial VCUG and renal cortical scars had no significant correlation with ultimate renal function.
conclusionOur study confirms the high prognostic significance of initial serum creatinine, PRA levels and GFR in cases with PUV. PRA also holds promise in long-term follow-up of these patients as a marker of progressive renal damage.
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