ArticleEvolution & development
Gonad morphogenesis defects drive hybrid male sterility in asymmetric hybrid breakdown of Caenorhabditis nematodes.
Article in Evolution & development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Conserved Gene Expression Plasticity in Development Is More Pervasive Than Expression Divergence Between Species of Caenorhabditis Nematodes.Evolution & development · 2025Article
- Aberrant X chromosome dosage compensation causes hybrid male inviability inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phylogenomic timetree-calibrated speciation clocks for Caenorhabditis nematodes reveal slow but disproportionate accumulation of post-zygotic reproductive isolation.PLoS genetics · 2025Article
- Five new Caenorhabditis species from Indonesia provide exceptions to Haldane's rule and partial fertility of interspecific hybrids.G3 (Bethesda, Md.) · 2025Article
- Hybrid incompatibility emerges at the one-cell stage in interspecies Caenorhabditis embryos.Current biology : CB · 2025Article
- Five newbioRxiv : the preprint server for biology · 2025Article
- Hybrid incompatibility emerges at the one-cell stage in interspeciesbioRxiv : the preprint server for biology · 2025Article
- Experimental evolution of hybrid populations to identify Dobzhansky-Muller incompatibility loci.Ecology and evolution · 2024Article
- Genome Size Changes by Duplication, Divergence, and Insertion in Caenorhabditis Worms.Molecular biology and evolution · 2023Article
- Nematode chromosomes.Genetics · 2022Review
- Genetic architecture and temporal analysis of Caenorhabditis briggsae hybrid developmental delay.PloS one · 2022Article
- Optimizing experimental design for genome sequencing and assembly with Oxford Nanopore Technologies.GigaByte (Hong Kong, China) · 2021Article
- The importance of intrinsic postzygotic barriers throughout the speciation process.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Molecular evolution across developmental time reveals rapid divergence in early embryogenesis.Evolution letters · 2019Article
- Specific Interactions Between Autosome andGenetics · 2019Article
- Genetic basis to hybrid inviability is more complex than hybrid male sterility in Caenorhabditis nematodes.Heredity · 2018Article
- Decontaminating eukaryotic genome assemblies with machine learning.BMC bioinformatics · 2017Article
- A rare exception to Haldane's rule: Are X chromosomes key to hybrid incompatibilities?Heredity · 2017Article
- Cytoplasmic-Nuclear Incompatibility Between Wild Isolates ofG3 (Bethesda, Md.) · 2017Article
- Suppression of F1 Male-Specific Lethality in Caenorhabditis Hybrids by cbr-him-8.G3 (Bethesda, Md.) · 2015Article
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4 authors at 1 institution in 1 country.
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Abstract
Determining the causes and evolution of reproductive barriers to gene flow between populations, speciation, is the key to understanding the origin of diversity in nature. Many species manifest hybrid breakdown when they intercross, characterized by increasingly exacerbated problems in later generations of hybrids. Recently, Caenorhabditis nematodes have emerged as a genetic model for studying speciation, and here we investigate the nature and causes of hybrid breakdown between Caenorhabditis remanei and C. latens. We quantify partial F1 hybrid inviability and extensive F2 hybrid inviability; the ~75% F2 embryonic arrest occurs primarily during gastrulation or embryonic elongation. Moreover, F1 hybrid males exhibit Haldane's rule asymmetrically for both sterility and inviability, being strongest when C. remanei serves as maternal parent. We show that the mechanism by which sterile hybrid males are incapable of transferring sperm or a copulatory plug involves defective gonad morphogenesis, which we hypothesize results from linker cell defects in migration and/or cell death during development. This first documented case of partial hybrid male sterility in Caenorhabditis follows expectations of Darwin's corollary to Haldane's rule for asymmetric male fitness, providing a powerful foundation for molecular dissection of intrinsic reproductive barriers and divergence of genetic pathways controlling organ morphogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.