Evidence map›Paper›PMID 25196834›Full record

ReviewMarine drugs2014

Effects of estrogens and estrogenic disrupting compounds on fish mineralized tissues.

Patricia I S Pinto, Maria D Estêvão, Deborah M Power

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Effects of 17α-Ethinylestradiol on Development and Gonadal Differentiation in the Estuarine Mummichog, Fundulus heteroclitus.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Article
  3. Review
  4. Review
  5. Review
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  8. Article
  9. Reproductive Toxicity of 3,4-dichloroaniline (3,4-DCA) on Javanese Medaka (Animals : an open access journal from MDPI · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Patricia I S PintoCCMAR-Centre of Marine Sciences, University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal. ppinto@ualg.pt.
Maria D EstêvãoCCMAR-Centre of Marine Sciences, University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal. mestevao@ualg.pt.
Deborah M PowerCCMAR-Centre of Marine Sciences, University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal. dpower@ualg.pt.
University of Algarve · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogens play well-recognized roles in reproduction across vertebrates, but also intervene in a wide range of other physiological processes, including mineral homeostasis. Classical actions are triggered when estrogens bind and activate intracellular estrogen receptors (ERs), regulating the transcription of responsive genes, but rapid non-genomic actions initiated by binding to plasma membrane receptors were recently described. A wide range of structurally diverse compounds from natural and anthropogenic sources have been shown to interact with and disrupt the normal functions of the estrogen system, and fish are particularly vulnerable to endocrine disruption, as these compounds are frequently discharged or run-off into waterways. The effect of estrogen disruptors in fish has mainly been assessed in relation to reproductive endpoints, and relatively little attention has been given to other disruptive actions. This review will overview the actions of estrogens in fish, including ER isoforms, their expression, structure and mechanisms of action. The estrogen functions will be considered in relation to mineral homeostasis and actions on mineralized tissues. The impact of estrogenic endocrine disrupting compounds on fish mineralized tissues will be reviewed, and the potential adverse outcomes of exposure to such compounds will be discussed. Current lacunae in knowledge are highlighted along with future research priorities.

Indexed as

AnimalsEndocrine DisruptorsEstrogensFishesHumansMineralsProtein IsoformsReceptors, EstrogenReproductionEndocrine DisruptorsEstrogensMineralsProtein IsoformsReceptors, Estrogen

Identifiers

PMID25196834
PMCPMC4145326
OpenAlexW2108480706

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.