ArticleNeurobiology of learning and memory2014
Noradrenergic actions in the basolateral complex of the amygdala modulate Arc expression in hippocampal synapses and consolidation of aversive and non-aversive memory.
Article in Neurobiology of learning and memory, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Direct electrical stimulation of the amygdala enhances declarative memory in humans.Proceedings of the National Academy of Sciences of the United States of America · 2018Trial
- Sex-specific exploration patterns and noradrenergic modulation in object recognition memory: Role of the perirhinal cortex.Psychopharmacology · 2026Article
- Possible Role of Dopamine in the Enhancement of Intrahippocampal Arc Protein Expression Induced by Post-Learning Noradrenergic Stimulation of the Basolateral Amygdala.International journal of molecular sciences · 2026Article
- Predatory Odor Exposure as a Potential Paradigm for Studying Emotional Modulation of Memory Consolidation-The Role of the Noradrenergic Transmission in the Basolateral Amygdala.International journal of molecular sciences · 2024Article
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
- Article
- Neuronal circuitry for recognition memory of object and place in rodent models.Neuroscience and biobehavioral reviews · 2022Review
- Post-training intra-basolateral complex of the amygdala infusions of clenbuterol enhance memory for conditioned place preference and increase ARC protein expression in dorsal hippocampal synaptic fractions.Neurobiology of learning and memory · 2021Article
- Amygdala-hippocampal interactions in synaptic plasticity and memory formation.Neurobiology of learning and memory · 2021Review
- The medial entorhinal cortex mediates basolateral amygdala effects on spatial memory and downstream activity-regulated cytoskeletal-associated protein expression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- The peripheral effect of direct current stimulation on brain circuits involving memory.Science advances · 2020Article
- Glucocorticoid enhancement of recognition memory via basolateral amygdala-driven facilitation of prelimbic cortex interactions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Contextual fear memory modulates PSD95 phosphorylation, AMPAr subunits, PKMζ and PI3K differentially between adult and juvenile rats.Neurobiology of stress · 2019Article
- Norepinephrine Induces PTSD-Like Memory ImpairmentsFrontiers in behavioral neuroscience · 2019Article
- Optogenetic Stimulation of the Basolateral Amygdala Increased Theta-Modulated Gamma Oscillations in the Hippocampus.Frontiers in behavioral neuroscience · 2019Article
- ACSS2-related autophagy has a dual impact on memory.Chinese neurosurgical journal · 2019Review
- Basolateral Amygdala Inputs to the Medial Entorhinal Cortex Selectively Modulate the Consolidation of Spatial and Contextual Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Administration of a Histone Deacetylase Inhibitor into the Basolateral Amygdala Enhances Memory Consolidation, Delays Extinction, and Increases Hippocampal BDNF Levels.Frontiers in pharmacology · 2017Article
- Object Phobia and Altered RhoA Signaling in Amygdala of Mice Lacking RICH2.Frontiers in molecular neuroscience · 2017Article
- The amygdala and prioritization of declarative memories.Current directions in psychological science · 2016Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The basolateral complex of the amygdala (BLA) plays a role in the modulation of emotional memory consolidation through its interactions with other brain regions. In rats, memory enhancing infusions of the β-adrenergic receptor agonist clenbuterol into the BLA immediately after training enhances expression of the protein product of the immediate early gene Arc in the dorsal hippocampus and memory-impairing intra-BLA treatments reduce hippocampal Arc expression. We have proposed that the BLA may modulate memory consolidation through an influence on the local translation of synaptic plasticity proteins, like Arc, in recently active synapses in efferent brain regions. To date, all work related to this hypothesis is based on aversive memory tasks such as inhibitory avoidance (IA). To determine whether BLA modulation of hippocampal Arc protein expression is specific to plasticity associated with inhibitory avoidance memory, or a common mechanism for multiple types of memory, we tested the effect of intra-BLA infusions of clenbuterol on memory and hippocampal synaptic Arc expression following IA or object recognition training. Results indicate that intra-BLA infusions of clenbuterol enhance memory for both tasks; however, Arc expression in hippocampal synaptoneurosomes was significantly elevated only in rats trained on the aversive IA task. These findings suggest that regulation of Arc expression in hippocampal synapses may depend on co-activation of arousal systems. To test this hypothesis, a "high arousal" version of the OR task was used where rats were not habituated to the testing conditions. Posttraining intra-BLA infusions of clenbuterol enhanced consolidation of the high-arousing version of the task and significantly increased Arc protein levels in dorsal hippocampus synaptic fractions. These findings suggest that the BLA modulates multiple forms of memory and affects the synaptic plasticity-associated protein Arc in synapses of the dorsal hippocampus when emotional arousal is elevated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.