SynthesisThe Journal of urology2015
Efficacy of antibiotic prophylaxis in children with vesicoureteral reflux: systematic review and meta-analysis.
Synthesis in The Journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- A Systematic Review of the (Un)known Host Immune Response Biomarkers for Predicting Recurrence of Urinary Tract Infection.Frontiers in medicine · 2022Pooled it
- Antibiotic prophylaxis for prevention of urinary tract infections in the first year of life in children with vesicoureteral reflux diagnosed in the workup of antenatal hydronephrosis: a systematic review.Pediatric nephrology (Berlin, Germany) · 2020Pooled it
- Uropathogen Resistance and Antibiotic Prophylaxis: A Meta-analysis.Pediatrics · 2018Pooled it
- Design and Methodological Considerations of the Centers for Disease Control and Prevention Urologic and Renal Protocol for the Newborn and Young Child with Spina Bifida.The Journal of urology · 2016Guideline
- Renal Scarring in the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) Trial.Clinical journal of the American Society of Nephrology : CJASN · 2016Trial
- Swiss Consensus on Prenatal and Early Postnatal Urinary Tract Dilation: Practical Approach and When to Refer.Children (Basel, Switzerland) · 2024Review
- Impact of antibiotic prophylaxis on urinary tract infection recurrence in children Rapid review.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Review
- Clinical characteristics and nomogram model for predicting the risk of recurrence of complicated urinary tract infection in pediatric patients.Scientific reports · 2024Article
- Antimicrobial resistance of breakthrough urinary tract infections in young children receiving continual antibiotic prophylaxis.European journal of pediatrics · 2023Article
- Antibiotic Prophylaxis for the Prevention of Urinary Tract Infections in Children: Guideline and Recommendations from the Emilia-Romagna Pediatric Urinary Tract Infections (UTI-Ped-ER) Study Group.Antibiotics (Basel, Switzerland) · 2023Review
- Prescribed daily-dose-based metrics of oral antibiotic use for hospitalized children in Japan.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2023Article
- Clinical guidelines of UTIs in children: quality appraisal with AGREE II and recommendations analysis.BMJ open · 2022Article
- Contemporary Management of Urinary Tract Infections in Children.Current treatment options in pediatrics · 2022Review
- Risk factors for breakthrough urinary tract infection in children with vesicoureteral reflux receiving continuous antibiotic prophylaxis.Translational pediatrics · 2022Article
- [Is there still no alternative to long-term antibacterial prophylaxis?]Der Urologe. Ausg. A · 2020Review
- Updated Italian recommendations for the diagnosis, treatment and follow-up of the first febrile urinary tract infection in young children.Acta paediatrica (Oslo, Norway : 1992) · 2020Review
- Current status of long-term antibiotic prophylaxis for urinary tract infections in children: An antibiotic stewardship challenge.Kidney research and clinical practice · 2019Review
- Primary vesicoureteral reflux; what have we learnt from the recently published randomized, controlled trials?Pediatric nephrology (Berlin, Germany) · 2019Review
- Susceptibility of the Index Urinary Tract Infection to Prophylactic Antibiotics Is a Predictive Factor of Breakthrough Urinary Tract Infection in Children with Primary Vesicoureteral Reflux Receiving Continuous Antibiotic Prophylaxis.Journal of Korean medical science · 2019Article
- Parental Preferences for Vesicoureteral Reflux Treatment: A Crowd-sourced, Best-worst Scaling Study.Urology · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeControversy exists regarding the use of continuous antibiotic prophylaxis vs observation in the management of children with vesicoureteral reflux. The reported effectiveness of continuous antibiotic prophylaxis in children with reflux varies widely. We determined whether the aggregated evidence supports use of continuous antibiotic prophylaxis in children with vesicoureteral reflux. MATERIALS AND
methodsWe searched the Cochrane Controlled Trials Register, clinicaltrials.gov, MEDLINE(®), EMBASE(®), Google Scholar and recently presented meeting abstracts for reports in any language. Bibliographies of included studies were then hand searched for any missed articles. The study protocol was prospectively registered at PROSPERO (No. CRD42014009639). Reports were assessed and data abstracted in duplicate, with differences resolved by consensus. Risk of bias was assessed using standardized instruments.
resultsWe identified 1,547 studies, of which 8 are included in the meta-analysis. Pooled results demonstrated that continuous antibiotic prophylaxis significantly reduced the risk of recurrent febrile or symptomatic urinary tract infection (pooled OR 0.63, 95% CI 0.42-0.96) but, if urinary tract infection occurred, increased the risk of antibiotic resistant organism (pooled OR 8.75, 95% CI 3.52-21.73). A decrease in new renal scarring was not associated with continuous antibiotic prophylaxis use. Adverse events were similar between the 2 groups. Significant heterogeneity existed between studies (I(2) 50%, p = 0.03), specifically between those trials with significant risk of bias (eg unclear protocol descriptions and/or lack of blinding).
conclusionsCompared to no treatment, continuous antibiotic prophylaxis significantly reduced the risk of febrile and symptomatic urinary tract infections in children with vesicoureteral reflux, although it increased the risk of infection due to antibiotic resistant bacteria. Continuous antibiotic prophylaxis did not significantly impact the occurrence of new renal scarring or reported adverse events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.