ArticleBMC genomics2014
Genome analysis of Campylobacter jejuni strains isolated from a waterborne outbreak.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Genetic Factors ofPathogens (Basel, Switzerland) · 2025Article
- Molecular Responses of the Eukaryotic Cell Line INT407 on the InternalizedPathogens (Basel, Switzerland) · 2024Article
- Whole-genome-based characterization ofMicrobial genomics · 2023Article
- Genomic insight intoFrontiers in veterinary science · 2023Article
- Cryptic Prophages Contribution forMicroorganisms · 2022Article
- Genomic adaptations of Campylobacter jejuni to long-term human colonization.Gut pathogens · 2021Article
- Analysis of Campylobacter jejuni Subtype Distribution in the Chicken Broiler Production Continuum: a Longitudinal Examination To Identify Primary Contamination Points.Applied and environmental microbiology · 2021Article
- Whole-Genome Sequencing to Detect Numerous Campylobacter jejuni Outbreaks and Match Patient Isolates to Sources, Denmark, 2015-2017.Emerging infectious diseases · 2020Article
- Whole-Genome Sequencing and Bioinformatic Analysis of Environmental, Agricultural, and HumanFrontiers in microbiology · 2020Article
- Investigating Major RecurringFrontiers in cellular and infection microbiology · 2020Article
- Genomic and Phenotypic Characterisation ofFrontiers in cellular and infection microbiology · 2020Article
- Whole genome sequencing and metagenomics for outbreak investigation, source attribution and risk assessment of food-borne microorganisms.EFSA journal. European Food Safety Authority · 2019Article
- Population Genetics and Characterization of Campylobacter jejuni Isolates from Western Jackdaws and Game Birds in Finland.Applied and environmental microbiology · 2019Article
- Developments in Rapid Detection Methods for the Detection of FoodborneFrontiers in microbiology · 2018Review
- Genomic Epidemiology ofFrontiers in microbiology · 2018Article
- Whole-Genome Sequencing in Epidemiology of Campylobacter jejuni Infections.Journal of clinical microbiology · 2017Review
- Food Safety in the Age of Next Generation Sequencing, Bioinformatics, and Open Data Access.Frontiers in microbiology · 2017Review
- Comparative genomic fingerprinting of Campylobacter: application in routine public health surveillance and epidemiological investigations.Epidemiology and infection · 2017Article
- Genomic insights from whole genome sequencing of four clonal outbreak Campylobacter jejuni assessed within the global C. jejuni population.BMC genomics · 2016Article
- Navigating Microbiological Food Safety in the Era of Whole-Genome Sequencing.Clinical microbiology reviews · 2016Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWaterborne Campylobacter jejuni outbreaks are common in the Nordic countries, and PFGE (pulsed field gel electrophoresis) remains the genotyping method of choice in outbreak investigations. However, PFGE cannot assess the clonal relationship between isolates, leading to difficulties in molecular epidemiological investigations. Here, we explored the applicability of whole genome sequencing to outbreak investigation by re-analysing three C. jejuni strains (one isolated from water and two from patients) from an earlier resolved Finnish waterborne outbreak from the year 2000.
resultsOne of the patient strains had the same PFGE profile, as well as an identical overall gene synteny and three polymorphisms in comparison with the water strain. However, the other patient isolate, which showed only minor differences in the PFGE pattern relative to the water strain, harboured several polymorphisms as well as rearrangements in the integrated element CJIE2. We reconstructed the genealogy of these strains with ClonalFrame including in the analysis four C. jejuni isolated from chicken in 2012 having the same PFGE profile and sequence type as the outbreak strains. The three outbreak strains exhibited a paraphyletic relationship, implying that the drinking water from 2000 was probably contaminated with at least two different, but related, C. jejuni strains.
conclusionsOur results emphasize the capability of whole genome sequencing to unambiguously resolve the clonal relationship between isolates of C. jejuni in an outbreak situation and evaluate the diversity of the C. jejuni population.
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